Respiratory symptoms and 30 year mortality from obstructive lung disease and pneumonia

Abstract

Background

As little is known about the long term relationship between respiratory symptoms and mortality from non‐malignant respiratory diseases, a study was undertaken to investigate the predictive value of respiratory symptoms and symptom load for mortality from obstructive lung disease (OLD) and pneumonia in the long term in a Norwegian population.

Methods

In 1972, 19 998 persons aged 15–70 years living in Oslo were randomly selected for a respiratory survey. The response rate was 89%. All were followed for 30 years. The association between cough, asthma‐like symptoms, two levels of dyspnoea on exercise, a symptom score, and mortality from OLD and pneumonia were investigated separately for men and women by multivariable analyses, with adjustment for age, occupational exposure to air pollution, and smoking habits.

Results

OLD accounted for 43% and pneumonia for 50% of all deaths from respiratory causes. In men the hazard ratio for mortality from OLD varied from 4.0 (95% confidence interval (CI) 2.4 to 6.5) for cough to 9.6 (95% CI 5.1 to 18.3) for severe dyspnoea, and in women from 5.1 (95% CI 2.3 to 11.3) for moderate dyspnoea to 13.0 (95% CI 6.0 to 28.3) for severe dyspnoea. The symptom score was strongly predictive of death from OLD in a dose‐response manner.

Conclusions

There is a significant, positive, strong association between respiratory symptoms and 30 year mortality from OLD. The association between respiratory symptoms and mortality from pneumonia is weaker and not significant.

Few population studies have focused on the predictive value of respiratory symptoms for mortality from obstructive lung disease (OLD)¹,² or pneumonia,³ although these diseases are the main causes of death from non‐malignant respiratory disease.⁴ There are known associations between respiratory symptoms and lung function⁵,⁶,⁷ and between lung function and several causes of death.¹,⁸,⁹,¹⁰ The results of lung function tests depend, however, on the instruments used, the time at which the tests are conducted, and the level of training of personnel. Recording of respiratory symptoms is a cheaper and easier screening method than conducting lung function tests.

Two population based studies showed associations between cough, dyspnoea, and mortality from all respiratory diseases combined;⁹,¹¹ one showed an association between wheezing and mortality from respiratory disease.⁹ Lange et al¹ found that persons who reported symptoms of chronic mucus hypersecretion had a higher risk of death from OLD, and Vandentorren et al² showed that persons reporting asthma or asthma symptoms had a higher risk of death from chronic obstructive lung disease (COPD).

Large cohorts are needed to observe a sufficient number of deaths due to cause‐specific respiratory diseases. In a previous paper we found a consistent positive association between respiratory symptoms reported and all cause mortality.¹² We therefore decided to extend the analyses to investigate the long term relationship between respiratory symptoms and mortality from non‐malignant respiratory diseases in this large cohort. In this paper we report the predictive value of self‐reported respiratory symptoms and the load of such symptoms on mortality from OLD and pneumonia over a 30 year period in a large population based sample covering nearly 500 000 person‐years.

Methods

Study population

The study population was derived from a cross sectional survey conducted in Oslo in 1972.¹³ The sample frame was an updated list from the Central Population Register of 345 630 persons aged 15–70 years living in Oslo on 1 June 1972. From this population a random sample of 19 998 persons was selected to receive a postal questionnaire. During autumn 1972, 163 persons in the random sample died or emigrated and were therefore excluded from the analysis. A total of 17 678 of the sample responded (response rate 89%). The observation start date was 1 January 1973, and respondents were followed up until the date of death or emigration or until 31 December 2002, whichever occurred first (all inhabitants of Norway have a unique personal identification number that allows complete follow up until death or emigration). By 31 December 2002 the population had been followed up for 30 years, contributing a total of 489 218 person‐years.

The baseline characteristics of the respondents are shown in table 1.

Table 1 Baseline characteristics at 1 January 1973 and crude mortality rate (MR) per 100 000 person‐years from obstructive lung disease (OLD) and pneumonia of respondents during follow up for 30 years by sex, respiratory symptoms, occupational exposure, and smoking habits.

Characteristic	Total at baseline (n = 17678)		Deaths from OLD (n = 250)		Deaths from pneumonia (n = 293)
	N	%	n	MR	n	MR
Sex
Men	8147	46	146	74	107	55
Women	9531	54	104	35	186	66
Respiratory symptoms*
None	8696	49	36	16	143	64
Symptom score
1–3	6272	36	86	55	95	60
4–6	1966	11	62	137	30	66
⩾7	712	4	66	511	23	178
Groups
Cough symptoms	5732	32	175	129	106	78
Asthma‐like symptoms	6092	34	182	107	90	61
Moderate dyspnoea on exercise	2298	13	53	101	28	37
Severe dyspnoea on exercise	851	5	59	383	24	156
Occupational exposure†
Yes	3138	18	82	88	47	47
No	13513	76	143	35	210	53
Smoking habit
Never	6567	37	24	14	117	69
Former	2011	11	25	51	44	90
Current (g tobacco/day)
<10	2521	14	31	48	35	55
10–19	4399	25	107	99	59	55
⩾20	1800	10	56	135	25	60
Unknown	262	2	3	48	8	129

*32 persons did not answer any questions about respiratory symptoms.

†1027 persons did not answer this question.

Questionnaire and variables used in the analysis

The questionnaire used was a modification of that published by the British Medical Research Council's Committee on Research into Chronic Bronchitis in 1966. The validity of the Norwegian questions on respiratory symptoms has been examined by various methods.¹⁴ The agreement between the British and the Norwegian questionnaires varied by 85–99%.¹⁵

The questionnaire contained 11 questions on respiratory symptoms which were pooled into four symptom groups (Appendix 1): cough symptoms (persons who answered “yes” to one of questions 8, 9, 10 or 11); asthma‐like symptoms (those who answered “yes” to one of questions 12, 17 or 18); moderate dyspnoea (those who answered “yes” to questions 13 or 14 but not to questions 15 or 16); and severe dyspnoea (subjects who answered “yes” to questions 15 or 16). The respondents were separated into three groups on the basis of their answers to questions about smoking habits: never smokers (those who had not smoked daily for more than 1 year); current smokers (those who had smoked daily for more than 1 year and were still smoking at the time of the survey); the remainder were defined as former smokers.¹³ Smoking was measured as daily tobacco consumption calculated on the basis that one cigarette  = 1 g tobacco. The amounts smoked by current smokers were grouped as <10 g, 10–19 g and ⩾20 g tobacco per day. For occupational exposure to air pollution, respondents were divided in two groups according to whether they answered “yes” or “no” to the question: “Have you been exposed to particles, gases or damp at your working place?”

Follow up

Notifications of death and causes of death were obtained from Statistics Norway with permission from the Data Inspectorate, the Norwegian Directorate of Health and Social Services, and the Regional Committee for Medical Research Ethics. The Norwegian death certificate is based on the international medical certificate recommended by the World Health Organization¹⁶ and physicians complete a certificate for every death. The certificate always gives the underlying cause of death and, if appropriate, contributing causes. The underlying cause is defined as the disease or injury that initiated the train of events leading to death. The contributory cause of death is often a disease that followed the underlying cause and that might have contributed to death. Norway used the 8th revision of the International Statistical Classification of Diseases, Injuries and Death (ICD) during the period 1970–85, the 9th revision up to 1995, and has used the 10th revision since 1996.

The coding and diagnosis of asthma and COPD have changed in Norway over the past 30 years.¹⁷ Many cases of COPD were previously coded as asthma when they had a similar pattern of symptoms and signs. To avoid misclassification, we pooled diagnoses related to asthma and COPD into OLD.

The analyses were based on mortality from OLD (ICD10 J40–J47) and pneumonia (ICD10 J12–J18)⁴ given as the underlying cause of death. Associations between respiratory symptoms and mortality from OLD and pneumonia were also estimated when the two diagnoses were given as either the underlying or the contributing cause of death.

Statistical methods

The association between each respiratory symptom group and mortality was expressed as an adjusted hazard ratio (HR) estimated from a Cox proportional hazard regression model.¹⁸ Mortality associated with each symptom group was compared with mortality among persons who had not reported any respiratory symptoms. A symptom score ranging from 0 to 11 was defined on the basis of the sum of affirmative answers to 11 equally weighted respiratory symptom questions. The scores were then grouped as 0 (no respiratory symptoms), 1–3, 4–6, and ⩾7 respiratory symptoms. Tests for trend were performed with symptom score and grams of tobacco smoked as continuous variables.

As mortality was more strongly associated with age than time in the study or calendar time, age was used as the underlying time scale.¹⁹,²⁰ The proportional hazard ratio assumption of the Cox model was derived with the test of Schoenfeld's residuals on partial likelihood.²¹ Information about physician diagnosed OLD and coronary heart disease were considered as steps in the causal chain between respiratory symptoms and mortality, and were therefore not treated as possible confounders. The analyses were also performed after excluding those individuals with these self‐reported physician diagnosed diseases.

The covariates added to the multivariable models as confounders were smoking habit and exposure to air pollution. Separate analyses were conducted for men and women. All analyses were performed using STATA‐9 (StataCorp, TX, USA).

Results

Of a total of 6710 deaths in the period 1973–2002, the underlying cause recorded was respiratory disease in 582, cardiovascular disease in 2881, and cancer in 1882. Of the deaths due to respiratory disease, OLD accounted for 250 (43%), pneumonia for 293 (50%), and other lung diseases for 39 (7%).

Among the 250 subjects in whom OLD was the underlying cause of death, no contributory cause was given in 16%, cardiovascular disease was the contributory cause in 36%, pneumonia in 20%, subgroups of OLD such as bronchitis, asthma and emphysema in 16%, and other diagnoses in 12%. Among the 293 subjects in whom pneumonia was the underlying cause of death, no contributory cause was given in 40%, senility and dementia were the contributory cause in 21%, cardiovascular disease in 10%, stroke sequelae in 5%, and other diagnoses such as diabetes, cancer and abdominal diseases in 24%. Of the 39 deaths due to other respiratory diseases, interstitial lung diseases accounted for 16, viral infections in the respiratory tract for 13, pulmonary hypertension for five, respiratory failure for two, and there were five other respiratory deaths without an exact diagnosis.

The crude mortality rate for OLD was higher for men than for women, while the opposite was true for pneumonia (table 1). When the contributory cause of death was included in the end points, the number of deaths from OLD increased by 105 to 355 and for pneumonia the number of deaths increased by 861 to 1154.

For persons reporting any respiratory symptoms, the crude mortality rate per 100 000 person‐years was 99 for OLD and 69 for pneumonia. The mortality rate for OLD increased significantly with increased reporting of respiratory symptoms, while that from pneumonia showed a weaker dose–response association (table 1). Of the 23 individuals who died from pneumonia with seven or more respiratory symptoms, 17 had physician diagnosed OLD or other respiratory disease.

The crude mortality rate for OLD was 2.5 times higher among persons exposed to dust or gases at work than in those not so exposed, while there was little difference in mortality from pneumonia. The crude mortality rate for OLD was lowest for never smokers, but a dose‐response relation was found between the mortality rate and amount smoked in current smokers. The mortality rate due to pneumonia was highest for former smokers and did not differ by amount smoked for current smokers (table 1).

The association between each respiratory symptom group and death from OLD showed a considerable increase in the risk of mortality in both sexes: the HR was ⩾4.0 for all symptom groups and ⩾10 for those with severe dyspnoea (table 2). No significant association was found between respiratory symptom group and death from pneumonia. Mortality from OLD increased in a dose‐dependent manner with the symptom score. Symptom score did not significantly increase the HR for mortality from pneumonia, except in women with ⩾7 symptoms.

Table 2 Hazard ratio (HR) with 95% confidence interval (CI) for mortality from obstructive lung disease and pneumonia as underlying cause of death by respiratory symptom groups, symptom score and sex, adjusted for occupational exposure, smoking habits, and age in Norway, 1973–2002: separate models for each symptom group.

Symptom	Obstructive lung disease (n = 250)				Pneumonia (n = 293)
	Men		Women		Men		Women
	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
No respiratory symptoms	1.0		1.0		1.0		1.0
Symptom group
Cough symptoms	4.0	2.4 to 6.5	6.2	3.1 to 12.3	1.5	0.9 to 2.4	1.2	0.8 to 1.8
Asthma‐like symptoms	4.7	2.9 to 7.7	7.8	4.0 to 15.0	1.2	0.7 to 2.1	1.3	0.8 to 1.8
Moderate dyspnoea	4.5	2.5 to 8.3	5.1	2.3 to 11.3	1.2	0.5 to 2.7	0.8	0.4 to 1.3
Severe dyspnoea	9.6	5.1 to 18.3	13.0	6.0 to 28.3	1.5	0.5 to 4.6	1.5	0.9 to 2.7
Symptom score
1–3	2.3	1.4 to 4.0	3.4	1.7 to 6.8	1.5	1.0 to 2.4	0.9	0.6 to 1.3
4–6	4.1	2.3 to 7.5	9.6	4.5 to 20.8	1.5	0.7 to 3.2	1.1	0.6 to 1.9
⩾7	13.6	7.1 to 25.9	21.5	9.4 to 49.5	2.0	0.6 to 6.2	3.0	1.5 to 6.0
p trend for symptom score	<0.001		<0.001		0.09		0.02

The adjusted HR for mortality from OLD associated with the question “Do you have cough for 3 months or more altogether during a year?” was 7.4 (95% CI 4.2 to 13.1) for men and 13.3 (95% CI 6.0 to 29.4) for women, and that for mortality from pneumonia was 1.6 (95% CI 0.7 to 3.5) for men and 2.3 (95% CI 1.2 to 4.0) for women. After exclusion of individuals who reported physician diagnosed asthma, bronchitis or emphysema at baseline, the association between “cough for 3 months or more …” and mortality from OLD was 4.0 (95% CI 2.4 to 6.5) in men and 6.2 (95% CI 3.1 to 12.3) in women.

Up to 1986 all death certificates were based on clinical diagnoses. Causes of death based on autopsies were available for the period 1986–2002. During this period the proportion of clinical death diagnoses regarding OLD were 78% and 88% in the periods 1986–1995 and 1996–2003, respectively. The corresponding proportions for pneumonia deaths were 89% and 98%. With regard to autopsies, mortality from OLD represented 17% (32/184) of the underlying causes of death and pneumonia represented 7% (16/247). After adjustment for age, sex, occupational exposure and smoking habits, the HR for mortality from autopsy confirmed OLD varied from 3.7 (95% CI 2.4 to 5.7) for cough to 6.3 (95% CI 3.4 to 11.6) for severe dyspnoea. The HR for mortality from autopsy confirmed pneumonia based on symptoms, however, was not significant.

The results of the final multivariable model with all four symptom groups are shown in table 3. The association between respiratory symptoms and mortality from OLD was, as expected, weaker when all symptoms were included in the same model and adjusted for each other than when each symptom group was investigated separately. Nevertheless, for all respiratory symptom groups in men and for asthma‐like symptoms and severe dyspnoea in women, the HR was still significantly increased. None of the respiratory symptoms was a significant predictor of deaths due to pneumonia.

Table 3 Age adjusted hazard ratio (HR) with 95% confidence interval (CI) for mortality from obstructive lung disease and pneumonia as underlying causes of death by respiratory symptom, sex, occupational exposure, and smoking habits in Norway, 1973–2002: one model.

Symptoms	Obstructive lung disease (n = 250)				Pneumonia (n = 293)
	Men		Women		Men		Women
	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
No respiratory symptoms	1.0		1.0		1.0		1.0
Cough symptoms	2.3	1.5 to 3.7	1.5	0.9 to 2.5	1.5	0.9 to 2.5	1.2	0.8 to 1.8
Asthma‐like symptoms	2.0	1.3 to 3.0	4.0	2.3 to 7.1	0.8	0.5 to 1.4	1.4	0.9 to 2.1
Moderate dyspnoea	1.5	1.0 to 2.4	1.1	0.6 to 2.0	0.8	0.3 to 1.7	0.6	0.4 to 1.1
Severe dyspnoea	3.3	2.1 to 5.3	2.8	1.6 to 4.8	1.2	0.4 to 3.5	1.2	0.7 to 2.1
Occupational exposure
No	1.0		1.0		1.0		1.0
Yes	1.4	1.1 to 2.1	0.7	0.4 to 1.3	0.8	0.5 to 1.3	0.9	0.5 to 1.5
Smoking
Never	1.0		1.0		1.0		1.0
Former	7.4	1.7 to 31.8	0.6	0.1 to 2.7	1.5	0.7 to 2.6	1.6	1.0 to 2.6
Current (g tobacco/day)
<10	7.9	1.8 to 35.2	2.6	1.3 to 5.2	1.5	0.7 to 3.3	1.1	0.7 to 1.8
10–19	13.0	3.1 to 53.6	5.2	2.9 to 9.4	1.8	0.9 to 3.4	1.2	0.7 to 1.9
⩾20	19.9	4.8 to 83.2	5.9	2.7 to 13.0	2.1	1.0 to 4.7	2.7	1.2 to 5.7
p trend for daily smoking	<0.001		<0.001		0.04		0.08

There was a significant association between smoking habits and mortality from OLD, even after adjustment for respiratory symptoms, except for former smoking in women. The association between smoking and mortality from pneumonia was significant for men and women current smokers who smoked more than 20 g tobacco per day. Occupational exposure to air pollution was also a significant predictor of deaths from OLD among men when smoking and symptom groups were taken into account.

After exclusion of 3656 persons who reported physician diagnosed asthma, bronchitis or emphysema at baseline, the association between all respiratory symptoms and mortality from OLD was still significantly increased for both men and women (table 4). The HR for mortality from OLD and pneumonia did not change after further exclusion of 4146 persons who reported physician diagnosed heart failure or cardiovascular disease.

Table 4 Hazard ratio (HR) with 95% confidence interval (CI) for mortality from obstructive lung disease and pneumonia as underlying causes of death by respiratory symptoms and sex, adjusted for smoking habit, occupational exposure, and age in Norway, 1973–2002. Persons who reported physician diagnosed asthma, bronchitis or emphysema are excluded. Separate models for each symptom group.

Symptoms	Obstructive lung disease (n = 112)				Pneumonia (n = 243)
	Men		Women		Men		Women
	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
No respiratory symptoms	1.0		1.0		1.0		1.0
Cough symptoms	2.5	1.4 to 4.6	3.1	1.2 to 7.8	1.6	1.0 to 2.7	1.1	0.7 to 1.8
Asthma‐like symptoms	2.9	1.6 to 5.5	4.5	1.9 to 10.9	1.4	0.8 to 2.5	1.3	0.8 to 2.0
Moderate dyspnoea	2.3	1.0 to 5.3	3.3	1.1 to 9.6	1.1	0.5 to 2.8	0.8	0.4 to 1.6
Severe dyspnoea	4.2	1.5 to 11.7	4.6	1.4 to 14.7	1.4	0.3 to 5.9	1.2	0.5 to 2.5

The HR for mortality from OLD decreased during follow up for all respiratory symptoms in both sexes and was still significantly increased in the third decade, except in men reporting severe dyspnoea. The HR for the third decade varied from 2.5 (95% CI 1.3 to 4.8) to 3.0 (95% CI 1.2 to 7.3) for men and from 5.0 (95% CI 1.7 to 14) to 6.7 (95% CI 2.7 to 16) for women.

The magnitude of the associations between OLD and symptom groups did not change after OLD was added as a contributory cause (table 5). When pneumonia was added as a contributory cause of death, however, the HR for mortality from pneumonia was slightly higher for most symptom groups.

Table 5 Hazard ratio (HR) with 95% confidence interval (CI) for mortality from obstructive lung disease and pneumonia as underlying or contributory causes of death, by respiratory symptoms and sex, adjusted for occupational exposure, smoking, and age in Norway, 1973–2002: separate models for each symptom group.

Symptoms	Obstructive lung disease (n = 355)				Pneumonia (n = 1154)
	Men		Women		Men		Women
	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
No respiratory symptoms	1.0		1.0		1.0		1.0
Cough	4.1	2.9 to 5.9	4.2	2.7 to 6.5	1.5	1.2 to 1.8	1.2	1.0 to 1.5
Asthma‐like symptoms	4.6	3.2 to 6.7	5.0	3.3 to 7.6	1.5	1.3 to 1.9	1.2	0.9 to 1.5
Moderate dyspnoea	5.1	3.3 to 7.1	4.0	2.4 to 6.6	1.6	1.2 to 2.2	1.2	0.9 to 1.5
Severe dyspnoea	12.7	8.0 to 20.2	8.5	5.1 to 14.2	2.7	1.9 to 3.9	1.8	1.4 to 2.4

Discussion

We found a significant, positive, strong predictive value of respiratory symptoms for mortality from OLD over 30 years in nearly 18 000 men and women in Oslo. The relative risk for mortality decreased slightly during follow up but was still significantly increased in the third decade after recording of symptoms. The predictive value of respiratory symptoms for mortality from pneumonia was weaker and not significant. When causes contributory to the underlying cause of death were added, the association between mortality from pneumonia and respiratory symptoms changed slightly.

The large number of persons and the long follow up in our study resulted in a large number of deaths, making it possible to estimate the relative risk for mortality from OLD and pneumonia. The individuals were selected randomly and they answered the questionnaire at home, thus reducing sampling and observer bias, respectively. As there was no connection between how they answered the questionnaire and the outcome, there was no outcome‐dependent bias. As the 11‐digit unique personal identification number used in Norway and because Statistics Norway, by law, records all deaths in the country, the estimates are not distorted by incomplete follow up.

The main source of uncertainty with regard to cause of death is the diagnosis, and physicians' reporting on the death certificates is potentially the largest source of error. In addition, the coding of diagnoses has changed, and three different ICD systems were used during the period. Uncertain associations can lead to non‐differential misclassification of diagnoses and will alter the association between respiratory symptoms and mortality.²² One of the gold standards of diagnosing cause of death is, however, the autopsy. In our study the risk for mortality from OLD and pneumonia based on autopsies was similar to that for the whole cohort, thus strengthening our conclusions.

Smoking might be a strong confounder of the association between respiratory symptoms and outcome. Although we controlled for smoking habits before inclusion in the study, the prevalence of smoking in our cohort might have changed during follow up. Stavem et al²³ found that 32% of a Norwegian cohort of middle aged men had quit smoking and only 16% had started smoking or started smoking again. In addition, the total proportion of daily smokers among Norwegian men and women decreased during the follow up period.⁴ Some of the respondents might have stopped smoking in response to the Norwegian Tobacco Act and to educational programmes on smoking and health.²⁴ As a considerable proportion of the persons who smoked and reported symptoms might have had fewer symptoms after quitting during follow up,²⁵ our analysis probably underestimates rather than overestimates the relation between symptoms and mortality.

There was an increased risk of death from OLD among smokers, which was two to three times higher among male than female current smokers. A similar trend was reported by Lange et al.¹

A positive association has been reported between chronic mucus hypersecretion—that is, chronic cough with phlegm >3 months a year—and death from COPD in several studies, most conducted in an occupational setting,²⁶,²⁷,²⁸ although Peto et al²⁷ found that death from COPD was not significantly related to mucus hypersecretion. In a population based study, Lange et al¹ found a significant association between chronic mucus hypersecretion and mortality from OLD. In the Danish study the HR was adjusted for lung function. We did not have any information about lung function but we did have information about reported physician diagnosed asthma, bronchitis, or emphysema. We believe that there is an accumulation of individuals with low lung function among those with already diagnosed OLD. When excluding those individuals, we exclude the majority of subjects with low lung function. In our study, all the questions about cough were pooled into one cough symptom group. However, when we analysed reports of cough and phlegm for at least 3 months per year for at least 1 year separately with exclusion of those individuals with reported physician diagnosed asthma, bronchitis or emphysema, the HR for mortality from OLD was 1.5 times higher than in the Danish study. This could be explained by the reference populations; in the Danish study the reference population reported not having that symptom, while in our study the reference population had no respiratory symptoms at all. In line with the findings in Denmark,¹ we found that the association between respiratory symptoms and mortality from OLD were similar when OLD was included as the underlying and contributory cause or only as the underlying cause of death.

With regard to asthma‐like symptoms, Knuiman et al⁹ found that persons who reported wheezing had increased mortality from respiratory disease in general, and Carpenter et al²⁹ confirmed this finding for mortality from chronic bronchitis. Vandentorren et al² found that having asthma or asthma symptoms such as attacks of breathlessness associated with wheezing was significantly associated with mortality from COPD, with a relative risk of 3.5. In our study, asthma‐like symptoms—that is, at least one of the symptoms wheezing, attacks of breathlessness or long lasting cough after a cold—resulted in a higher HR for mortality from OLD than in the study of Vandentorren et al.²,⁹

Our finding of a significant association between the degree of dyspnoea symptoms and death from OLD is in agreement with those of previous epidemiological surveys.⁹,¹¹,²⁸,²⁹ Dyspnoea on exercise is frequently a presenting symptom of both lung and heart disease. An affirmative answer to having severe dyspnoea could be an indicator of organ failure with a poor prognosis and is therefore an important predictor for mortality from OLD.

When all symptoms were adjusted for each other in the same model, the risk associated with each respiratory symptom decreased, probably because some of the symptoms are expressions of the same pathological entity in the airways. Except for cough and moderate dyspnoea in women, the risk for mortality was still significantly increased.

The crude mortality rate for death from pneumonia was higher in subjects who reported ⩾7 respiratory symptoms than in those who reported <7 respiratory symptoms. Among these individuals, 74% reported physician diagnosed OLD or other respiratory disease. This could indicate that OLD is underestimated as an underlying cause of death. We found a slightly increased risk of death from pneumonia associated with reports of respiratory symptoms, and the relative risk increased with increasing number of respiratory symptoms reported. Except when ⩾7 respiratory symptoms were reported in women, the association between symptoms and mortality from pneumonia was not significant, in agreement with the study by Lange et al.³ Persons who died from pneumonia had fewer respiratory symptoms at baseline and were on average 8 years older at the time of death than those who died of OLD. These observations might explain the lack of association between respiratory symptoms and mortality due to pneumonia.

Our study does not elucidate the mechanisms by which respiratory symptoms cause earlier death or why a single self‐report of symptoms has such a long lasting effect on mortality rates. We have nevertheless shown that common respiratory symptoms are important predictors of mortality from OLD over a period of 30 years. We believe that this information is easily obtained and should be kept in mind by physicians in clinical practice.

Appendix 1 Respiratory symptoms and questions defining them

	Question in 1972 questionnaire	Respiratory symptom in our study
8	Do you usually cough and clear your throat in the morning?	Cough symptoms
9	Do you usually cough during the day?
10	When you cough or clear your throat, do you usually bring up phlegm?
11	Do you have cough for 3 months or more altogether during a year?
12	During the last 2 years, have you had a cough and/or phlegm in connection with a cold for more than 3 weeks?	Asthma‐like symptoms
17	Do you have attacks of breathlessness?
18	Have you ever had wheezing in your chest?
13	Are you more breathless than people of your own age when walking uphill?	Moderate dyspnoea on exercise
14	Are you breathless when you climb two flights of stairs at an ordinary pace?
15	Are you breathless when you walk on level ground at an ordinary pace?	Severe dyspnoea on exercise
16	Are you breathless when at rest?