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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1906 Jan 25;8(1):8–58. doi: 10.1084/jem.8.1.8

ON THE PHYSIOLOGY OF HEART-BLOCK IN MAMMALS, WITH ESPECIAL REFERENCE TO THE CAUSATION OF STOKES-ADAMS DISEASE

Joseph Erlanger 1
PMCID: PMC2124603  PMID: 19867033

Abstract

The facts collected in the third part of this paper justify the following conclusions: (1) All of the cardinal symptoms of Stokes-Adams disease may be duplicated by heart-block resulting from a lesion in or near the auriculo-ventricular bundle of His, and by this alone. (2) No typical case of Stokes-Adams disease has been described in which heart-block might not have been the cause of the trouble. (3) It can be shown that all cases of Stokes-Adams disease which have been studied by sufficiently accurate methods were cases of heart-block. (4) It would appear that heart-block without and with syncopal attacks are two stages of the same disease process.

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