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. 1912 Mar 1;15(3):287–291. doi: 10.1084/jem.15.3.287

THE PRODUCTION OF ANTIBODIES BY TISSUES LIVING OUTSIDE OF THE ORGANISM

Alexis Carrel 1, Ragnvald Ingebrigtsen 1
PMCID: PMC2124919  PMID: 19867523

Abstract

Since guinea pig bone marrow and lymph gland cultivated for five days with goat blood generate substances that are hemolytic for goat red blood corpuscles, it can be concluded that tissues living outside of the organism react against an antigen by the production of an antibody.

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Selected References

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  1. Carrel A., Burrows M. T. CULTIVATION OF TISSUES IN VITRO AND ITS TECHNIQUE. J Exp Med. 1911 Mar 1;13(3):387–396. doi: 10.1084/jem.13.3.387. [DOI] [PMC free article] [PubMed] [Google Scholar]

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