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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1913 Oct 1;18(4):416–427. doi: 10.1084/jem.18.4.416

RESISTANCE TO A TUMOR-PRODUCING AGENT AS DISTINCT FROM RESISTANCE TO THE IMPLANTED TUMOR CELLS

OBSERVATIONS WITH A SARCOMA OF THE FOWL.

Peyton Rous 1
PMCID: PMC2125084  PMID: 19867717

Abstract

Ultraviolet light rapidly kills the cells of a transplantable sarcoma of the fowl without notably injuring the etiological agent associated therewith. The Roentgen ray has little effect on either cells or agent. Fowls manifest two sorts of resistance to the avian tumor, one directed against the implanted tumor cells as such, the other against the action of the etiological agent to cause a neoplastic change. In the individual fowl the two resistances appear to be independent of one another, though they may exist together or may both be absent. A recognition of them will perhaps explain some features in the biology of other tumors.

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Selected References

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  1. Rous P., Murphy J. B. THE HISTOLOGICAL SIGNS OF RESISTANCE TO A TRANSMISSIBLE SARCOMA OF THE FOWL. J Exp Med. 1912 Mar 1;15(3):270–286. doi: 10.1084/jem.15.3.270. [DOI] [PMC free article] [PubMed] [Google Scholar]

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