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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1913 May 1;17(5):542–546. doi: 10.1084/jem.17.5.542

THE RENAL LESION OF EXPERIMENTAL CANTHARIDIN POISONING

Richard M Pearce 1
PMCID: PMC2125087  PMID: 19867666

Abstract

Although the study of experimental nephritis by physiological methods shows that the most striking effect of cantharidin is injury of the blood vessels, the great abundance of mitotic figures in the tubular epithelium in the stage of repair points to an equally widespread and severe epithelial injury. Caution must therefore be observed in ascribing the physiological disturbances of kidney function caused by cantharidin as due exclusively to a vascular injury, and in regarding cantharidin nephritis as a pure type of vascular nephritis.

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Selected References

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  1. Opie E. L. LYMPH FORMATION AND EDEMA OF THE LIVER WITH EXPERIMENTAL NEPHRITIS PRODUCED BY CANTHARIDIN. J Exp Med. 1912 Dec 1;16(6):831–849. doi: 10.1084/jem.16.6.831. [DOI] [PMC free article] [PubMed] [Google Scholar]

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