Abstract
1. The intravenous injection of killed organisms is followed by the mobilization of a non-specific protease and lipase; the rapidity and extent of this reaction depend upon the toxicity of the organism and on the resistance of the organism to proteolysis. 2. The temperature and leucocytic curve bear no relation to the ferment changes. 3. The serum antiferment is usually increased after the injection. 4. Of the organisms studied, the typhoid bacilli produced the most marked ferment changes, and the tubercle bacilli the least. 5. The toxicity of the dried organisms cannot depend wholly upon proteolysis in vivo, but must depend in part on the preformed toxic substances liberated on lysis. 6. Serum protease should not be considered as the sole exciter of intoxication through the production of protein split products; it seems possible that its function may in part be one of detoxication.
Full Text
The Full Text of this article is available as a PDF (433.5 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cole R. PNEUMOCOCCUS HEMOTOXIN. J Exp Med. 1914 Oct 1;20(4):346–362. doi: 10.1084/jem.20.4.346. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jobling J. W., Eggstein A. A., Petersen W. SERUM PROTEASES AND THE MECHANISM OF THE ABDERHALDEN REACTION : STUDIES ON FERMENT ACTION. XX. J Exp Med. 1915 Mar 1;21(3):239–249. doi: 10.1084/jem.21.3.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jobling J. W., Petersen W. BACTERIAL ANTIFERMENTS : STUDIES ON FERMENT ACTION. XVII. J Exp Med. 1914 Nov 1;20(5):452–467. doi: 10.1084/jem.20.5.452. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jobling J. W., Petersen W., Eggstein A. A. SERUM FERMENTS AND ANTIFERMENT AFTER FEEDING : STUDIES ON FERMENT ACTION. XXI. J Exp Med. 1915 Aug 1;22(2):129–140. doi: 10.1084/jem.22.2.129. [DOI] [PMC free article] [PubMed] [Google Scholar]