Abstract
In spite of numerous abnormalities or non-experimental lesions in the rabbit certain facts can be considered as established. It has been known for many years that pneumonia is produced by the more or less prolonged inhalation of high partial pressures of oxygen. The studies herein reported show that atmospheres containing 80 to 96 per cent oxygen under normal barometric pressure produce in 24 hours, or more commonly 48 hours, congestion, edema, epithelial degeneration and desquamation, fibrin formation, and finally a pneumonia, probably of irritative origin and to be described as a fibrinous bronchopneumonia. The important new points are the time relations of these changes and definition of the type of the pneumonia. Other studies have noted slight passive congestion, but it is now established that this is to be accounted for in most cases by dilatation of the right side or of both sides of the heart. This congestion affects all the abdominal viscera and is accompanied by certain secondary changes such as cloudy swelling of the parenchymatous organs and phagocytosis of erythrocytes by endothelial cells of the mesenteric lymph nodes. Although deficiency of oxygen may affect the hematopoietic system, the animals subjected to high oxygen percentages failed to show any demonstrable pathologic changes in blood, spleen, lymph nodes, or bone marrow, except for the presence of congestion. This study is the first of a comprehensive series projected in and under the direction of the Carnegie Nutrition Laboratory. Different animals and various methods of attack will be employed in the investigation.
Full Text
The Full Text of this article is available as a PDF (1.4 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bunting C. H. EXPERIMENTAL ANAEMIAS IN THE RABBIT. J Exp Med. 1906 Oct 12;8(5):625–646. doi: 10.1084/jem.8.5.625. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hill L., Macleod J. J. The influence of compressed air on the respiratory exchange. J Physiol. 1903 Jun 16;29(6):492–510. doi: 10.1113/jphysiol.1903.sp000970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hill L., Macleod J. J. The influence of compressed air on the respiratory exchange. J Physiol. 1903 Jun 16;29(6):492–510. doi: 10.1113/jphysiol.1903.sp000970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karsner H. T., Amiral H. H., Bock A. V. A Study of the Influence of Splenectomy and of certain Organs and Organ extracts on the Hemopsonins of the Blood Serum. J Med Res. 1914 Jul;30(3):383–391. [PMC free article] [PubMed] [Google Scholar]
- Karsner H. T., Pearce R. M. THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : IV. A STUDY, BY THE METHODS OF IMMUNOLOGY, OF THE INCREASED RESISTANCE OF THE RED BLOOD CORPUSCLES AFTER SPLENECTOMY. J Exp Med. 1912 Dec 1;16(6):769–779. doi: 10.1084/jem.16.6.769. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parkinson J. The effect of inhalation of oxygen on the rate of the pulse in health. J Physiol. 1912 Mar 29;44(1-2):54–58. doi: 10.1113/jphysiol.1912.sp001501. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pearce R. M., Austin J. H. THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : V. CHANGES IN THE ENDOTHELIAL CELLS OF THE LYMPH NODES AND LIVER IN SPLENECTOMIZED ANIMALS RECEIVING HEMOLYTIC SERUM. J Exp Med. 1912 Dec 1;16(6):780–788. doi: 10.1084/jem.16.6.780. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith J. L. The pathological effects due to increase of oxygen tension in the air breathed. J Physiol. 1899 Mar 22;24(1):19–35. doi: 10.1113/jphysiol.1899.sp000746. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith J. L. The pathological effects due to increase of oxygen tension in the air breathed. J Physiol. 1899 Mar 22;24(1):19–35. doi: 10.1113/jphysiol.1899.sp000746. [DOI] [PMC free article] [PubMed] [Google Scholar]