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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1916 Mar 1;23(3):419–429. doi: 10.1084/jem.23.3.419

THE INFLUENCE OF TYPHOID BACILLI ON THE ANTIBODIES OF NORMAL AND IMMUNE RABBITS

Carroll G Bull 1
PMCID: PMC2125417  PMID: 19867996

Abstract

The subcutaneous, intraperitoneal, or intravenous inoculation of cultures of typhoid bacilli did not cause, as far as could be determined, a decrease in the antibody content of the blood serum of the rabbit. On the other hand, the intravenous inoculation of typhoid bacilli causes a rapid mobilization of normal antibodies, thus increasing their concentration in the blood, to be followed somewhat later, as in the other forms of inoculation, by the production of so called acquired antibodies. No such condition as the negative phase of Wright was discovered, although especially looked for in the experiments.

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Selected References

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  1. Bull C. G. THE FATE OF TYPHOID BACILLI WHEN INJECTED INTRAVENOUSLY INTO NORMAL RABBITS. J Exp Med. 1915 Oct 1;22(4):475–483. doi: 10.1084/jem.22.4.475. [DOI] [PMC free article] [PubMed] [Google Scholar]

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