Abstract
1. The presence of an acidosis in dogs with experimental uranium nephritis is demonstrable by the Van Slyke-Stillman-Cullen method and that of Marriott. It is detected more readily by the former method. 2. This acidosis is associated with increase in the blood urea and plasma chlorides and with the appearance of albumin and casts in the urine. 3. The oral administration of sodium bicarbonate diminishes the acidosis, the increase in plasma chlorides, the amount of albumin and casts in the urine, and, to a lesser degree, the increase in the blood urea following the administration of uranium. It also diminishes the severity of the changes produced by uranium in the kidneys. 4. The oral administration of sodium bicarbonate to normal dogs raises the carbon dioxide content of the plasma as determined by the. Van Slyke-Stillman-Cullen method.
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Selected References
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- Christian H. A., O'Hare J. P. Study XIX : Glomerular Lesions in Acute experimental (Uranium) Nephritis in the Rabbit. J Med Res. 1913 May;28(1):227–234.11. [PMC free article] [PubMed] [Google Scholar]
- Macnider W. D. THE INHIBITION OF THE TOXICITY OF URANIUM NITRATE BY SODIUM CARBONATE, AND THE PROTECTION OF THE KIDNEY ACUTELY NEPHROPATHIC FROM URANIUM FROM THE TOXIC ACTION OF AN ANESTHETIC BY SODIUM CARBONATE. J Exp Med. 1916 Feb 1;23(2):171–187. doi: 10.1084/jem.23.2.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Opie E. L., Alford L. B. THE INFLUENCE OF DIET UPON NECROSIS CAUSED BY HEPATIC AND RENAL POISONS : PART II. DIET AND THE NEPHRITIS CAUSED BY POTASSIUM CHROMATE, URANIUM NITRATE, OR CHLOROFORM. J Exp Med. 1915 Jan 1;21(1):21–37. doi: 10.1084/jem.21.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pearce R. M., Hill M. C., Eisenbrey A. B. EXPERIMENTAL ACUTE NEPHRITIS: THE VASCULAR REACTIONS AND THE ELIMINATION OF NITROGEN. J Exp Med. 1910 Mar 14;12(2):196–226. doi: 10.1084/jem.12.2.196. [DOI] [PMC free article] [PubMed] [Google Scholar]