Abstract
Suspensions of the central nervous tissues of monkeys, containing the active filterable virus of poliomyelitis, may be injected into the brain of rabbits without setting up symptoms, provided the volume of injection does not cause dangerous increased intracranial pressure. Aside from the pressure effects which develop quickly, no other symptoms or pathological lesions are produced by the suspensions. The active virus of poliomyelitis survives in the brain of rabbits for 4 days, as determined by tests in the monkey, into which the excised site of injection in the rabbit brain is reinoculated. It cannot be detected by this test after the expiration of 7 days. The virus of poliomyelitis is unadapted to the rabbit, and neither induces lesions nor survives long in the central nervous organs of that animal. In this respect it differs from certain streptococci cultivated from poliomyelitic tissues. A monkey immunized to streptococcus cultivated from human poliomyelitic nervous tissues yielded a serum which agglutinated the streptococcus in high dilution, but was without neutralizing action on the filtered virus; and the streptococcus-immune monkey was not protected against the effects of an intracerebral inoculation of the filtered virus. The experiments recorded provide additional reasons for concluding that the streptococcus cultivated from cases of poliomyelitis differs essentially from the filterable virus and is not the microbic cause of epidemic poliomyelitis.
Full Text
The Full Text of this article is available as a PDF (244.8 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Amoss H. L. A NOTE ON THE ETIOLOGY OF EPIDEMIC POLIOMYELITIS. J Exp Med. 1914 Feb 1;19(2):212–216. doi: 10.1084/jem.19.2.212. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bull C. G. THE PATHOLOGIC EFFECTS OF STREPTOCOCCI FROM CASES OF POLIOMYELITIS AND OTHER SOURCES. J Exp Med. 1917 Apr 1;25(4):557–580. doi: 10.1084/jem.25.4.557. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Flexner S., Noguchi H. EXPERIMENTS ON THE CULTIVATION OF THE MICROORGANISM CAUSING EPIDEMIC POLIOMYELITIS. J Exp Med. 1913 Oct 1;18(4):461–485. doi: 10.1084/jem.18.4.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rosenow E. C., Towne E. B., Wheeler G. W. ON THE ETIOLOGY OF EPIDEMIC POLIOMYELITIS. Science. 1916 Oct 27;44(1139):614–614. doi: 10.1126/science.44.1139.614. [DOI] [PubMed] [Google Scholar]