Skip to main content
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1918 Aug 1;28(2):193–212. doi: 10.1084/jem.28.2.193

RENAL FUNCTION IN EXPERIMENTAL HYDRONEPHROSIS

Reuben A Johnson 1
PMCID: PMC2126262  PMID: 19868250

Abstract

Complete obstruction of the ureter causes atrophy of the renal parenchyma, especially marked in the portions lateral to the renal sinus. The longer the duration of the obstruction, the greater is the degree of atrophy. If the obstruction is removed within 2 weeks the kidney may regain its normal structure except for a varying amount of atrophy in the lateral portions. Kidneys obstructed for 2 weeks or less may regain their normal function, as measured by the phthalein test. The longer the period of obstruction, the slower is the rate of recovery. A hydronephrosis of 7 days' duration required 40 days, and one of 14 days' duration required 152 days to recover normal function.

Full Text

The Full Text of this article is available as a PDF (1.5 MB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brodie T. G., Cullis W. C. On the secretion of urine. J Physiol. 1906 May 31;34(3):224–249. doi: 10.1113/jphysiol.1906.sp001153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cushny A. R. On saline diuresis. J Physiol. 1902 Dec 15;28(6):431–447. doi: 10.1113/jphysiol.1902.sp000928. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Sollmann T., Williams W. W., Briggs C. E. EXPERIMENTAL ATRESIA OF THE URETER. J Exp Med. 1907 Jan 23;9(1):71–81. doi: 10.1084/jem.9.1.71. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES