Abstract
The experiments reported in this paper show that it is possible to render mice resistant to transplanted cancer by injections of a suitable quantity of olive oil. In the course of the development of the resistance a definite period of latency is detectable following the oil injection, and the maximum degree of resistance appears at about the 10th day. This state of resistance, as has been determined by histological studies, is preceded by a proliferation of the cells of the lymphoid germ centers and, after the cancer inoculation, is associated with a lymphoid infiltration about the grafts, as well as by a second stimulation of the lymphoid germ centers and an increase in the number of the circulating lymphocytes.
Full Text
The Full Text of this article is available as a PDF (887.8 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Murphy J. B., Nakahara W., Sturm E. STUDIES ON LYMPHOID ACTIVITY : V. RELATION BETWEEN THE TIME AND EXTENT OF LYMPHOID STIMULATION INDUCED BY PHYSICAL AGENTS AND THE DEGREE OF RESISTANCE TO CANCER IN MICE. J Exp Med. 1921 Mar 31;33(4):423–428. doi: 10.1084/jem.33.4.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Murphy J. B. TRANSPLANTABILITY OF TISSUES TO THE EMBRYO OF FOREIGN SPECIES : ITS BEARING ON QUESTIONS OF TISSUE SPECIFICITY AND TUMOR IMMUNITY. J Exp Med. 1913 Apr 1;17(4):482–493. doi: 10.1084/jem.17.4.482. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nakahara W., Murphy J. B. STUDIES ON X-RAY EFFECTS : VII. EFFECT OF SMALL DOSES OF X-RAYS OF LOW PENETRATION ON THE RESISTANCE OF MICE TO TRANSPLANTED CANCER. J Exp Med. 1921 Mar 31;33(4):429–432. doi: 10.1084/jem.33.4.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woglom W. H. THE DURATION AND EXTENT OF INDUCED RESISTANCE TOWARD TUMOR TRANSPLANTATION IN MICE. J Exp Med. 1912 Nov 1;16(5):629–643. doi: 10.1084/jem.16.5.629. [DOI] [PMC free article] [PubMed] [Google Scholar]