Abstract
1. Pure strains of mononuclear leucocytes were isolated from the blood of adult chickens and keptin active condition for nearly 3 months. 2. The cultures were composed of large mononuclear leucocytes which migrated and proliferated in vitro at a slower rate than fibroblasts. The cells had no tendency to form a tissue, as do fibroblasts and epithelial cells. They were much less resistant than fibroblasts. 3. Differentiation of the large mononuclears into cells assuming the appearance of fibroblasts took place under certain conditions. 4. The activity of the large mononuclears was increased by embryonic tissue juice and inhibited by homologous serum.
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Selected References
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- Carrel A. CONTRIBUTIONS TO THE STUDY OF THE MECHANISM OF THE GROWTH OF CONNECTIVE TISSUE. J Exp Med. 1913 Sep 1;18(3):287–298. doi: 10.1084/jem.18.3.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carrel A., Ebeling A. H. THE MULTIPLICATION OF FIBROBLASTS IN VITRO. J Exp Med. 1921 Sep 30;34(4):317–337. doi: 10.1084/jem.34.4.317. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carrel A., Ingebrigtsen R. THE PRODUCTION OF ANTIBODIES BY TISSUES LIVING OUTSIDE OF THE ORGANISM. J Exp Med. 1912 Mar 1;15(3):287–291. doi: 10.1084/jem.15.3.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carrel A. PURE CULTURES OF CELLS. J Exp Med. 1912 Aug 1;16(2):165–168. doi: 10.1084/jem.16.2.165. [DOI] [PMC free article] [PubMed] [Google Scholar]