Abstract
Mice bred at The Rockefeller Institute vary in their susceptibility to mouse typhoid infection caused by a certain strain of Bacillus pestis caviæ. This graded variation may be roughly analyzed as follows: in any series infected per os with a fixed dose, 20 to 30 per cent show no sign of infection, no positive blood cultures, and no agglutinins; 5 or 10 per cent present symptoms of disease, positive blood cultures, and then recover with or without homologous agglutinins; 70 or 80 per cent develop positive blood cultures and succumb in a more or less constant ratio relative to time. The strain of Bacillus pestis caviæ employed throughout a 10 month series of experiments has shown no permanent change in virulence. Blood cultures taken from infected mice early in disease, shortly after death, and 6 days after death, chronic stool carrier cultures, and chronic septicemia cultures, all show approximately the same degree of virulence.
Full Text
The Full Text of this article is available as a PDF (1.1 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Amoss H. L. EXPERIMENTAL EPIDEMIOLOGY : I. AN ARTIFICIALLY INDUCED EPIDEMIC OF MOUSE TYPHOID. J Exp Med. 1922 Jun 30;36(1):25–43. doi: 10.1084/jem.36.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Amoss H. L. EXPERIMENTAL EPIDEMIOLOGY : II. EFFECT OF THE ADDITION OF HEALTHY MICE TO A POPULATION SUFFERING FROM MOUSE TYPHOID. J Exp Med. 1922 Jun 30;36(1):45–69. doi: 10.1084/jem.36.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Webster L. T. EXPERIMENTS ON NORMAL AND IMMUNE MICE WITH A BACILLUS OF MOUSE TYPHOID. J Exp Med. 1922 Jun 30;36(1):71–96. doi: 10.1084/jem.36.1.71. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Webster L. T. IDENTIFICATION OF A PARATYPHOID-ENTERITIDIS STRAIN ASSOCIATED WITH EPIZOOTICS OF MOUSE TYPHOID. J Exp Med. 1922 Jun 30;36(1):97–105. doi: 10.1084/jem.36.1.97. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Webster L. T. MICROBIC VIRULENCE AND HOST SUSCEPTIBILITY IN PARATYPHOID-ENTERITIDIS INFECTION OF WHITE MICE. I. J Exp Med. 1923 Jun 30;38(1):33–44. doi: 10.1084/jem.38.1.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Webster L. T. THE INTESTINAL FLORA IN MOUSE TYPHOID INFECTION. J Exp Med. 1923 Jan 1;37(1):21–32. doi: 10.1084/jem.37.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]