Skip to main content
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1923 Jan 1;37(1):21–32. doi: 10.1084/jem.37.1.21

THE INTESTINAL FLORA IN MOUSE TYPHOID INFECTION

Leslie T Webster 1
PMCID: PMC2128403  PMID: 19868710

Abstract

The normal flora of laboratory mice at The Rockefeller Institute, fed on a bread and milk diet, was determined. Bacillus acidophilus and Bacillus bifidus outnumber the Bacillus coli, Bacillus acidi lactici, and Bacillus coli communior group about twenty-five to one. White and yellow cocci which may or may not liquefy gelatin are occasionally noted; spirochetal and vibrio forms and yeasts are usually seen in stained preparations. This flora does not change when mice are artificially infected per os with a strain of mouse typhoid bacilli (Bacillus pestis cavice) and is the same in the animals which resist the infection as in those which succumb. Mice fed on a meat diet and showing a colon, Bacillus diffluens, and Bacillus welchii flora do not differ in susceptibility to mouse typhoid from the normal mice fed on bread and milk and showing the above acidophilus flora.

Full Text

The Full Text of this article is available as a PDF (471.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown J. H. AN IMPROVED ANAEROBE JAR. J Exp Med. 1921 May 31;33(6):677–681. doi: 10.1084/jem.33.6.677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Dochez A. R., Avery O. T. THE OCCURRENCE OF CARRIERS OF DISEASE-PRODUCING TYPES OF PNEUMOCOCCUS. J Exp Med. 1915 Jul 1;22(1):105–113. doi: 10.1084/jem.22.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gates F. L., Olitsky P. K. FACTORS INFLUENCING ANAEROBIOSIS, WITH SPECIAL REFERENCE TO THE USE OF FRESH TISSUE. J Exp Med. 1921 Jan 1;33(1):51–68. doi: 10.1084/jem.33.1.51. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Webster L. T. EXPERIMENTS ON NORMAL AND IMMUNE MICE WITH A BACILLUS OF MOUSE TYPHOID. J Exp Med. 1922 Jun 30;36(1):71–96. doi: 10.1084/jem.36.1.71. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES