Abstract
By means of a method differing in important details from those of previous investigators it has been determined that the blood serum of cases of leprosy exhibits the ability to fix complement with a wide variety of antigens including to a greater or less extent those derived from any culture of the acid-fast group of bacteria available to us. This property of multiple fixation may sufficiently characterize the disease to be of diagnostic significance, although our experience is hardly sufficient to enable us to speak with complete assurance on this point. Certainly, control sera from normal individuals, from cases of tuberculosis, or from cases of syphilis as obtained in our locality have entirely failed to react with certain antigens, whereas serum from cases of leprosy have so reacted to the extent of over 93 per cent. The most characteristic fixation given by the leprosy sera is that with Bacillus lepræ (Clegg) used as antigen, either in the form of a bacterial emulsion or of an alcoholic extract of the dried culture. Antibody absorption may be demonstrated in the acid-fast group if the absorbing bacteria are removed by filtration. Otherwise the resulting fluid is strongly anticomplementary. Leper serum is not deprived of the complement-fixing body when so treated with either Bacillus tuberculosis or Bacillus lepræ (Clegg).
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Selected References
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- Duval C. W., Gurd E. B. EXPERIMENTAL IMMUNITY WITH REFERENCE TO THE BACILLUS OF LEPROSY : PART I. A STUDY OF THE FACTORS DETERMINING INFECTION IN ANIMALS. J Exp Med. 1911 Aug 1;14(2):181–195. doi: 10.1084/jem.14.2.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Duval C. W., Harris W. H. Further Studies upon the Leprosy Bacillus. Its Cultivation and Differentiation from other Acid-fast Species. J Med Res. 1913 May;28(1):165–198. [PMC free article] [PubMed] [Google Scholar]
- Harris W. H., Lanford J. A. The Agglutination Reaction with Sera derived from Human Cases of Leprosy and from the experimental Animal upon various Members of the acid-fast Group. J Med Res. 1916 May;34(2):157–167. [PMC free article] [PubMed] [Google Scholar]
- Wolbach S. B., Honeij J. A. A critical Review of the Bacteriology of Human and Rat Leprosy. J Med Res. 1914 Jan;29(3):367–423. [PMC free article] [PubMed] [Google Scholar]