Skip to main content
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1924 Feb 29;39(3):335–346. doi: 10.1084/jem.39.3.335

GROWTH-INHIBITORY SUBSTANCES IN PNEUMOCOCCUS CULTURES

Hugh J Morgan 1, Oswald T Avery 1
PMCID: PMC2128471  PMID: 19868849

Abstract

The known factors concerned in the autoinhibition of growth of pneumococcus are: 1. The accumulation of acid products of metabolism, resulting in unfavorable reaction changes in the medium. 2. The exhaustion of the nutritive substances of the medium. 3. Under certain cultural conditions the formation and accumulation of peroxide in the medium.

Full Text

The Full Text of this article is available as a PDF (559.4 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Avery O. T., Cullen G. E. HYDROGEN ION CONCENTRATION OF CULTURES OF PNEUMOCOCCI OF THE DIFFERENT TYPES IN CARBOHYDRATE MEDIA. J Exp Med. 1919 Oct 1;30(4):359–378. doi: 10.1084/jem.30.4.359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Avery O. T., Cullen G. E. STUDIES ON THE ENZYMES OF PNEUMOCOCCUS : I. PROTEOLYTIC ENZYMES. J Exp Med. 1920 Oct 31;32(5):547–569. doi: 10.1084/jem.32.5.547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Avery O. T., Cullen G. E. STUDIES ON THE ENZYMES OF PNEUMOCOCCUS : II. LIPOLYTIC ENZYMES: ESTERASE. J Exp Med. 1920 Oct 31;32(5):571–582. doi: 10.1084/jem.32.5.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Avery O. T., Morgan H. J. THE OCCURRENCE OF PEROXIDE IN CULTURES OF PNEUMOCOCCUS. J Exp Med. 1924 Jan 31;39(2):275–287. doi: 10.1084/jem.39.2.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cole R. PNEUMOCOCCUS HEMOTOXIN. J Exp Med. 1914 Oct 1;20(4):346–362. doi: 10.1084/jem.20.4.346. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dochez A. R., Avery O. T. ANTIBLASTIC IMMUNITY. J Exp Med. 1916 Jan 1;23(1):61–68. doi: 10.1084/jem.23.1.61. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. McLeod J. W., Gordon J. Production of Hydrogen Peroxide by Bacteria. Biochem J. 1922;16(4):499–506. doi: 10.1042/bj0160499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Morgan H. J., Avery O. T. STUDIES ON BACTERIAL NUTRITION : IV. EFFECT OF PLANT TISSUE UPON GROWTH OF PNEUMOCOCCUS AND STREPTOCOCCUS. J Exp Med. 1923 Jul 31;38(2):207–217. doi: 10.1084/jem.38.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES