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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1924 Nov 30;40(6):845–871. doi: 10.1084/jem.40.6.845

STUDIES ON THE MATURATION OF MYELOBLASTS INTO MYELOCYTES AND ON AMITOTIC CELL DIVISION IN THE PERIPHERAL BLOOD IN SUBACUTE MYELOBLASTIC LEUCEMIA

F R Sabin 1, C R Austrian 1, R S Cunningham 1, C A Doan 1
PMCID: PMC2128605  PMID: 19868963

Abstract

1. Myeloblasts can be discriminated in the supravital technique by the great numbers of tiny mitochondria in the cytoplasm and the absence of any other vitally stainable substance. 2. There are three stages in the maturation of myelocytes. 3. These three phases can be correlated with three types of the oxidase reaction. 4. One case of myeloblastic leucemia showed such an amount of an abnormal type of amitosis as to suggest the disordered cell division of neoplasms. 5. In this case transfusions were correlated with a maturation of myeloblasts into myelocytes, with an increase of the oxidase reaction, and with an increase in amitosis.

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