Skip to main content
NCBI home page
The Journal of Hygiene logoLink to The Journal of Hygiene
. 1984 Apr;92(2):231–242. doi: 10.1017/s0022172400064251

Serological evaluation of an influenza A virus cold-adapted reassortant live vaccine, CR-37 (H1N1), in Japanese adult volunteers.

N Yamane, Y Nakamura, M Yuki, T Odagiri, N Ishida
PMCID: PMC2129243  PMID: 6707472

Abstract

A cold-adapted influenza A virus, CR-37 (H1N1), derived from genetic reassortment between A/Ann Arbor/6/60 (H2N2) cold-adapted variant virus and A/California/10/78 (H1N1) wild-type virus, was tested in Japanese adult volunteer. The CR-37 live virus preparation induced only low-grade clinical reactions in volunteers for the first 3-4 days after inoculation. Two vaccinees who did not show any antibody changes became febrile (over 38.0 degrees C). Skin tests using the vaccine preparation and uninfected allantoic fluid were performed, and indicated that one of these two vaccines was positive for the CR-37 vaccine preparation. A high proportion of the vaccinees whose sera had a haemagglutination-inhibition (HI) antibody titre against the vaccine strain of less than or equal to 64 before inoculation, seroconverted in both HI and neuraminidase-inhibition (NAI) antibody titrations, and only a few seroconverted in the titration of antibody against type-specific internal antigens. The serological examinations against heterotypic H1N1 variants indicated that the cold-adapted live influenza virus vaccine could induce a broad spectrum of HI antibody reactivity and immunity of long duration.

Full text

PDF
231

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chanock R. M., Murphy B. R. Use of temperature-sensitive and cold-adapted mutant viruses in immunoprophylaxis of acute respiratory tract disease. Rev Infect Dis. 1980 May-Jun;2(3):421–432. doi: 10.1093/clinids/2.3.421. [DOI] [PubMed] [Google Scholar]
  2. Lazar A., Okabe N., Wright P. F. Humoral and cellular immune responses of seronegative children vaccinated with a cold-adapted influenza A/HK/123/77 (H1N1) recombinant virus. Infect Immun. 1980 Mar;27(3):862–866. doi: 10.1128/iai.27.3.862-866.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Lerman S. J., Wright P. F., Patil K. D. Antibody decline in children following A/New Jersey/76 influenza virus immunization. J Pediatr. 1980 Feb;96(2):271–274. doi: 10.1016/s0022-3476(80)80823-7. [DOI] [PubMed] [Google Scholar]
  4. Maassab H. F. Adaptation and growth characteristics of influenza virus at 25 degrees c. Nature. 1967 Feb 11;213(5076):612–614. doi: 10.1038/213612a0. [DOI] [PubMed] [Google Scholar]
  5. Maassab H. F., Cox N. J., Murphy B. R., Kendal A. P. Biological, genetic and biochemical characterization of a cold-adapted recombinant A/Victoria/3/75 virus and its evaluation in volunteers. Dev Biol Stand. 1977 Jun 1;39:25–31. [PubMed] [Google Scholar]
  6. Maassab H. F., Francis T., Jr, Davenport F. M., Hennessy A. V., Minuse E., Anderson G. Laboratory and clinical characteristics of attenuated strains of influenza virus. Bull World Health Organ. 1969;41(3):589–594. [PMC free article] [PubMed] [Google Scholar]
  7. Maassab H. F., Kendal A. P., Abrams G. D., Monto A. S. Evaluation of a cold-recombinant influenza virus vaccine in ferrets. J Infect Dis. 1982 Dec;146(6):780–790. doi: 10.1093/infdis/146.6.780. [DOI] [PubMed] [Google Scholar]
  8. Mortiz A. J., Kunz C., Hofman H., Liehl E., Reeve P., Maassab H. F. Studies with a cold-recombinant A/Victoria/3/75 (H3N2) virus. II. Evaluation in adult volunteers. J Infect Dis. 1980 Dec;142(6):857–860. doi: 10.1093/infdis/142.6.857. [DOI] [PubMed] [Google Scholar]
  9. Murphy B. R., Chanock R. M., Clements M. L., Anthony W. C., Sear A. J., Cisneros L. A., Rennels M. B., Miller E. H., Black R. E., Levine M. M. Evaluation of A/Alaska/6/77 (H3N2) cold-adapted recombinant viruses derived from A/Ann Arbor/6/60 cold-adapted donor virus in adult seronegative volunteers. Infect Immun. 1981 May;32(2):693–697. doi: 10.1128/iai.32.2.693-697.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Murphy B. R., Holley H. P., Jr, Berquist E. J., Levine M. M., Spring S. B., Maassab H. F., Kendal A. P., Chanock R. M. Cold-adapted variants of influenza A virus: evaluation in adult seronegative volunteers of A/Scotland/840/74 and A/Victoria/3/75 cold-adapted recombinants derived from the cold-adapted A/Ann Arbor/6/60 strain. Infect Immun. 1979 Feb;23(2):253–259. doi: 10.1128/iai.23.2.253-259.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Murphy B. R., Nelson D. L., Wright P. F., Tierney E. L., Phelan M. A., Chanock R. M. Secretory and systemic immunological response in children infected with live attenuated influenza A virus vaccines. Infect Immun. 1982 Jun;36(3):1102–1108. doi: 10.1128/iai.36.3.1102-1108.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Murphy B. R., Rennels M. B., Douglas R. G., Jr, Betts R. F., Couch R. B., Cate T. R., Jr, Chanock R. M., Kendal A. P., Maassab H. F., Suwanagool S. Evaluation of influenza A/Hong Kong/123/77 (H1N1) ts-1A2 and cold-adapted recombinant viruses in seronegative adult volunteers. Infect Immun. 1980 Aug;29(2):348–355. doi: 10.1128/iai.29.2.348-355.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Odagiri T., DeBorde D. C., Maassab H. F. Cold-adapted recombinants of influenza A virus in MDCK cells. I. Development and characterization of A/Ann Arbor/6/60 X A/Alaska/6/77 recombinant viruses. Virology. 1982 May;119(1):82–95. doi: 10.1016/0042-6822(82)90067-8. [DOI] [PubMed] [Google Scholar]
  14. Wright P. F., Okabe N., McKee K. T., Jr, Maassab H. F., Karzon D. T. Cold-adapted recombinant influenza A virus vaccines in seronegative young children. J Infect Dis. 1982 Jul;146(1):71–79. doi: 10.1093/infdis/146.1.71. [DOI] [PubMed] [Google Scholar]
  15. Wright P. F., Ross K. B., Thompson J., Karzon D. T. Influenza A infections in young children. Primary natural infection and protective efficacy of live-vaccine-induced or naturally acquired immunity. N Engl J Med. 1977 Apr 14;296(15):829–834. doi: 10.1056/NEJM197704142961501. [DOI] [PubMed] [Google Scholar]
  16. Yamane N., Hiratsuka M., Arikawa J., Odagiri T., Ishida N. Antibody responses after repeated influenza A virus immunizations among schoolchildren in Japan. J Hyg (Lond) 1981 Dec;87(3):383–392. doi: 10.1017/s002217240006962x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Yamane N., Yuki M., Nakamura Y. Single radial complement fixation test for assaying antibody to influenza virus type-specific antigens. J Clin Microbiol. 1983 Oct;18(4):837–843. doi: 10.1128/jcm.18.4.837-843.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Hygiene are provided here courtesy of Cambridge University Press

RESOURCES