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. 1984 Apr;92(2):223–229. doi: 10.1017/s002217240006424x

An investigation of antigenic drift of neuraminidases of influenza A (H1N1) viruses.

P Luther, K C Bergmann, J S Oxford
PMCID: PMC2129244  PMID: 6707471

Abstract

A newly developed lectin neuraminidase test (LNT) and a panel of mouse monoclonal and post-infection ferret antibodies have been used to analyse antigenic drift in N1 neuraminidases of influenza A viruses isolated between 1933 and 1957 and also between 1977 and 1980. Significant antigenic differences were detected among the 'early' (1933-57) viruses since the NA of viruses isolated one year apart could be distinguished serologically. The NA of the 're-emerged' virus A/USSR/92/77 (H1N1) was antigenically related but not identical to influenza A viruses isolated in 1949 (A/Paris/49 (H1N1), A/Geneva/49 (H1N1) which thus predates the previously observed antigenic similarity of A/USSR/77 with A/FW/50 (H1N1) virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aymard-Henry M., Coleman M. T., Dowdle W. R., Laver W. G., Schild G. C., Webster R. G. Influenzavirus neuraminidase and neuraminidase-inhibition test procedures. Bull World Health Organ. 1973;48(2):199–202. [PMC free article] [PubMed] [Google Scholar]
  2. BIRD G. W. ANTI-T IN PEANUTS. Vox Sang. 1964 Nov-Dec;9:748–749. doi: 10.1111/j.1423-0410.1964.tb04072.x. [DOI] [PubMed] [Google Scholar]
  3. Blok J., Air G. M. Sequence variation at the 3' end of the neuraminidase gene from 39 influenza type A viruses. Virology. 1982 Sep;121(2):211–229. doi: 10.1016/0042-6822(82)90162-3. [DOI] [PubMed] [Google Scholar]
  4. Hugentobler A. L., Schild G. C., Oxford J. S. Differences in the electrophoretic migration rates of polypeptides and RNAs of recent isolates of influenza B viruses. Arch Virol. 1981;69(3-4):197–207. doi: 10.1007/BF01317335. [DOI] [PubMed] [Google Scholar]
  5. Kendal A. P., Noble G. R., Skehel J. J., Dowdle W. R. Antigenic similarity of influenza A (H1N1) viruses from epidemics in 1977--1978 to "Scandinavian" strains isolated in epidemics of 1950--1951. Virology. 1978 Sep;89(2):632–636. doi: 10.1016/0042-6822(78)90207-6. [DOI] [PubMed] [Google Scholar]
  6. Kozlov J. V., Gorbulev V. G., Kurmanova A. G., Bayev A. A., Shilov A. A., Zhdanov V. M. On the origin of the H1N1 (A/USSR/90/77) influenza virus. J Gen Virol. 1981 Oct;56(Pt 2):437–440. doi: 10.1099/0022-1317-56-2-437. [DOI] [PubMed] [Google Scholar]
  7. Luther P., Klett G. E., Weber S., Pechmann H., Bergmann K. C. The lectin neuraminidase inhibition test: a new method for the detection of antibodies to neuraminidase. J Biol Stand. 1983 Apr;11(2):115–121. doi: 10.1016/s0092-1157(83)80034-1. [DOI] [PubMed] [Google Scholar]
  8. Nakajima K., Desselberger U., Palese P. Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950. Nature. 1978 Jul 27;274(5669):334–339. doi: 10.1038/274334a0. [DOI] [PubMed] [Google Scholar]
  9. Palese P., Schulman J. L. Differences in RNA patterns of influenza A viruses. J Virol. 1976 Mar;17(3):876–884. doi: 10.1128/jvi.17.3.876-884.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Palese P., Young J. F. Variation of influenza A, B, and C viruses. Science. 1982 Mar 19;215(4539):1468–1474. doi: 10.1126/science.7038875. [DOI] [PubMed] [Google Scholar]
  11. Paniker C. K. Serological relationships between the neuraminidases in influenza viruses. J Gen Virol. 1968 May;2(3):385–394. doi: 10.1099/0022-1317-2-3-385. [DOI] [PubMed] [Google Scholar]
  12. Scholtissek C., von Hoyningen V., Rott R. Genetic relatedness between the new 1977 epidemic strains (H1N1) of influenza and human influenza strains isolated between 1947 and 1957 (H1N1). Virology. 1978 Sep;89(2):613–617. doi: 10.1016/0042-6822(78)90203-9. [DOI] [PubMed] [Google Scholar]
  13. Skehel J. J., Schild G. C. The polypeptide composition of influenza A viruses. Virology. 1971 May;44(2):396–408. doi: 10.1016/0042-6822(71)90270-4. [DOI] [PubMed] [Google Scholar]
  14. Webster R. G., Hinshaw V. S., Laver W. G. Selection and analysis of antigenic variants of the neuraminidase of N2 influenza viruses with monoclonal antibodies. Virology. 1982 Feb;117(1):93–104. doi: 10.1016/0042-6822(82)90510-4. [DOI] [PubMed] [Google Scholar]
  15. Zhdanov V. M., Lvov D. K., Zakstelskaya L. Y., Yakhno M. A., Isachenko V. I., Braude N. A., Reznik V. I., Pysina T. V., Andreyev V. P., Podchernyaeva R. Y. Return of epidemic A1 (H1N1) influenza virus. Lancet. 1978 Feb 11;1(8059):294–295. doi: 10.1016/s0140-6736(78)90068-5. [DOI] [PubMed] [Google Scholar]

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