Abstract
The majority (85%) of shigella isolated in 1980 and 1981 in Korea were Shigella flexneri, the others were Sh. sonnei (14%) with only a small number of Sh. dysenteriae. Only 14 of the 459 strains of shigella isolated were susceptible to all 12 drugs tested, and 445 were resistant to three or more drugs. Strains multiply resistant to the six drugs, chloramphenicol (Cm), tetracycline (Tc), streptomycin (Sm), sulfisomidine (Su), ampicillin (Ap) and trimethoprim (Tp) were most frequently encountered, followed by those resistant to Cm, Tc, Sm, Su and Tp. The complete patterns of resistance to drugs except nalidixic acid and rifampin in approximately 73% of drug-resistant strains were co-transferred to Escherichia coli by conjugation, indicating that the resistance was R plasmid-mediated. Randomly selected R plasmids conferring various patterns of resistance markers were tested for the incompatibility groups, and almost all of them were classified into Inc FII. Two of three R plasmids conferring resistance to Cm, Tc, Sm and Su were classified into Inc B and one to Inc FII. Two R types with resistance markers of Cm, Tc, Sm and Ap were not classified with our standard plasmids used.
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- Anderson E. S. Origin of transferable drug-resistance factors in the enterobacteriaceae. Br Med J. 1965 Nov 27;2(5473):1289–1291. doi: 10.1136/bmj.2.5473.1289. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barada F. A., Jr, Guerrant R. L. Sulfamethoxazole- trimethoprim versus ampicillin in treatment of acute invasive diarrhea in adults. Antimicrob Agents Chemother. 1980 Jun;17(6):961–964. doi: 10.1128/aac.17.6.961. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bochner B. R., Huang H. C., Schieven G. L., Ames B. N. Positive selection for loss of tetracycline resistance. J Bacteriol. 1980 Aug;143(2):926–933. doi: 10.1128/jb.143.2.926-933.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chun D., Seol S. Y., Cho D. T., Tak R. Drug resistance and R plasmids in Salmonella typhi isolated in Korea. Antimicrob Agents Chemother. 1977 Feb;11(2):209–213. doi: 10.1128/aac.11.2.209. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chun D., Seol S. Y., Suh M. H. Transferable resistance to trimethoprim in Shigella. J Infect Dis. 1981 May;143(5):742–742. doi: 10.1093/infdis/143.5.742. [DOI] [PubMed] [Google Scholar]
- Datta N., Olarte J. R factors in strains of Salmonella typhi and Shigella dysenteriae 1 isolated during epidemics in Mexico: classification by compatibility. Antimicrob Agents Chemother. 1974 Mar;5(3):310–317. doi: 10.1128/aac.5.3.310. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Frost J. A., Rowe B. Plasmid-determined antibiotic resistance in Shigella flexneri isolated in England and Wales between 1974 and 1978. J Hyg (Lond) 1983 Feb;90(1):27–32. doi: 10.1017/s0022172400063798. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ishiguro N., Oka C., Sato G. Isolation of citrate-positive variants of Escherichia coli from domestic pigeons, pigs, cattle, and horses. Appl Environ Microbiol. 1978 Aug;36(2):217–222. doi: 10.1128/aem.36.2.217-222.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Olarte J., Filloy L., Galindo E. Resistance of Shigella dysenteriae type 1 to ampicillin and other antimicrobial agents: strains isolated during a dysentery outbreak in a hospital in Mexico City. J Infect Dis. 1976 May;133(5):572–575. doi: 10.1093/infdis/133.5.572. [DOI] [PubMed] [Google Scholar]
- Uhlin B. E., Nordström K. Plasmid incompatibility and control of replication: copy mutants of the R-factor R1 in Escherichia coli K-12. J Bacteriol. 1975 Nov;124(2):641–649. doi: 10.1128/jb.124.2.641-649.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yoshikawa M., Nagashima S., Matsushima S. Genetical distinction of R factors derived from Shigellae and Salmonellae. Jpn J Microbiol. 1971 Sep;15(5):425–436. doi: 10.1111/j.1348-0421.1971.tb00600.x. [DOI] [PubMed] [Google Scholar]