Abstract
The co-transfer of plasmid-borne genes governing resistance to gentamicin, tetracycline, erythromycin and chloramphenicol has been demonstrated on human and mouse skin. Two different gentamicin resistance plasmids have been studied in detail; both appear to have the ability to mobilize in vivo otherwise non-transferable resistance plasmids from coagulase-negative to coagulase-positive staphylococci. This emphasis the role of the skin in maintaining a pool of resistance genes available to pathogenic staphylococci.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cohen M. L., Wong E. S., Falkow S. Common R-plasmids in Staphylococcus aureus and Staphylococcus epidermidis during a nosocomial Staphylococcus aureus outbreak. Antimicrob Agents Chemother. 1982 Feb;21(2):210–215. doi: 10.1128/aac.21.2.210. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Engel H. W., Soedirman N., Rost J. A., van Leeuwen W. J., van Embden J. D. Transferability of macrolide, lincomycin, and streptogramin resistances between group A, B, and D streptococci, Streptococcus pneumoniae, and Staphylococcus aureus. J Bacteriol. 1980 May;142(2):407–413. doi: 10.1128/jb.142.2.407-413.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Forbes B. A., Schaberg D. R. Transfer of resistance plasmids from Staphylococcus epidermidis to Staphylococcus aureus: evidence for conjugative exchange of resistance. J Bacteriol. 1983 Feb;153(2):627–634. doi: 10.1128/jb.153.2.627-634.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Groves D. J. Interspecific relationships of antibiotic resistance in Staphylococcus sp.: isolation and comparison of plasmids determining tetracycline resistance in S. aureus and S. epidermidis. Can J Microbiol. 1979 Dec;25(12):1468–1475. doi: 10.1139/m79-227. [DOI] [PubMed] [Google Scholar]
- Jaffe H. W., Sweeney H. M., Nathan C., Weinstein R. A., Kabins S. A., Cohen S. Identity and interspecific transfer of gentamicin-resistance plasmids in Staphylococcus aureus and Staphylococcus epidermidis. J Infect Dis. 1980 Jun;141(6):738–747. doi: 10.1093/infdis/141.6.738. [DOI] [PubMed] [Google Scholar]
- Lacey R. W. Antibiotic resistance plasmids of Staphylococcus aureus and their clinical importance. Bacteriol Rev. 1975 Mar;39(1):1–32. doi: 10.1128/br.39.1.1-32.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McDonnell R. W., Sweeney H. M., Cohen S. Conjugational transfer of gentamicin resistance plasmids intra- and interspecifically in Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob Agents Chemother. 1983 Jan;23(1):151–160. doi: 10.1128/aac.23.1.151. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NOVICK R. P. ANALYSIS BY TRANSDUCTION OF MUTATIONS AFFECTING PENICILLINASE FORMATION IN STAPHYLOCOCCUS AUREUS. J Gen Microbiol. 1963 Oct;33:121–136. doi: 10.1099/00221287-33-1-121. [DOI] [PubMed] [Google Scholar]
- Naidoo J., Noble W. C. Transfer of gentamicin resistance between coagulase-negative and coagulase-positive staphylococci on skin. J Hyg (Lond) 1981 Apr;86(2):183–187. doi: 10.1017/s0022172400068893. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Naidoo J., Noble W. C. Transfer of gentamicin resistance between strains of Staphylococcus aureus on skin. J Gen Microbiol. 1978 Aug;107(2):391–393. doi: 10.1099/00221287-107-2-391. [DOI] [PubMed] [Google Scholar]
- Novick R. P., Edelman I., Schwesinger M. D., Gruss A. D., Swanson E. C., Pattee P. A. Genetic translocation in Staphylococcus aureus. Proc Natl Acad Sci U S A. 1979 Jan;76(1):400–404. doi: 10.1073/pnas.76.1.400. [DOI] [PMC free article] [PubMed] [Google Scholar]