Abstract
The genetics of gentamicin resistance in Staphylococcus aureus strains isolated during an outbreak of infection in dermatology department have been studied. The predominant strain of S. aureus did not appear to possess a plasmid mediating gentamicin resistance though one isolate yielded a plasmid coding for penicillin and gentamicin. Three distinct plasmids were isolated from other phage types of S. aureus which appeared towards the end of the epidemic. There appeared to be a stepwise loss of gentamicin resistance in the predominant strain.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bint A. J., George R. H., Healing D. E., Wise R., Davies M. An outbreak of infection caused by a gentamicin-resistant Staphylococcus aureus. J Clin Pathol. 1977 Feb;30(2):165–167. doi: 10.1136/jcp.30.2.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chattopadhyay B., Teli J. C. Gentamicin-resistant Staphylococcus aureus after topical therapy in general practice. J Hosp Infect. 1981 Sep;2(3):278–279. doi: 10.1016/0195-6701(81)90052-9. [DOI] [PubMed] [Google Scholar]
- Faden H., Neter E., McLaughlin S., Giacoia G. Gentamicin-resistant Staphylococcus aureus. Emergence in an intensive care nursery. JAMA. 1979 Jan 12;241(2):143–145. [PubMed] [Google Scholar]
- Graham D. R., Correa-Villasenor A., Anderson R. L., Vollman J. H., Baine W. B. Epidemic neonatal gentamicin-methicillin--resistant Staphylococcus aureus infection associated with nonspecific topical use of gentamicin. J Pediatr. 1980 Dec;97(6):972–978. doi: 10.1016/s0022-3476(80)80439-2. [DOI] [PubMed] [Google Scholar]
- Greenhood G. P., Hill D. L., Dixon R. E., Carter M. J., Kanto W. P. Changing phage typing patterns of epidemic gentamicin-resistant Staphylococcus aureus. Evidence for transmission of gentamicin resistance. Lancet. 1979 Feb 10;1(8111):289–291. doi: 10.1016/s0140-6736(79)90703-7. [DOI] [PubMed] [Google Scholar]
- Jaffe H. W., Sweeney H. M., Nathan C., Weinstein R. A., Kabins S. A., Cohen S. Identity and interspecific transfer of gentamicin-resistance plasmids in Staphylococcus aureus and Staphylococcus epidermidis. J Infect Dis. 1980 Jun;141(6):738–747. doi: 10.1093/infdis/141.6.738. [DOI] [PubMed] [Google Scholar]
- Lacey R. W. Antibiotic resistance plasmids of Staphylococcus aureus and their clinical importance. Bacteriol Rev. 1975 Mar;39(1):1–32. doi: 10.1128/br.39.1.1-32.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Naidoo J., Noble W. C. Transfer of gentamicin resistance between coagulase-negative and coagulase-positive staphylococci on skin. J Hyg (Lond) 1981 Apr;86(2):183–187. doi: 10.1017/s0022172400068893. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Naidoo J., Noble W. C. Transfer of gentamicin resistance between strains of Staphylococcus aureus on skin. J Gen Microbiol. 1978 Aug;107(2):391–393. doi: 10.1099/00221287-107-2-391. [DOI] [PubMed] [Google Scholar]
- Novick R. P., Murphy E., Gryczan T. J., Baron E., Edelman I. Penicillinase plasmids of Staphylococcus aureus: restriction-deletion maps. Plasmid. 1979 Jan;2(1):109–129. doi: 10.1016/0147-619x(79)90010-6. [DOI] [PubMed] [Google Scholar]
- Price E. H., Brain A., Dickson J. A. An outbreak of infection with a gentamicin and methicillin-resistant Staphylococcus aureus in a neonatal unit. J Hosp Infect. 1980 Sep;1(3):221–228. doi: 10.1016/0195-6701(80)90059-6. [DOI] [PubMed] [Google Scholar]
- Schaefler S., Jones D., Perry W., Ruvinskaya L., Baradet T., Mayr E., Wilson M. E. Emergence of gentamicin- and methicillin-resistant Staphylococcus aureus strains in New York City hospitals. J Clin Microbiol. 1981 Apr;13(4):754–759. doi: 10.1128/jcm.13.4.754-759.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shanson D. C., Kensit J. C., Duke R. Outbreak of hospital infection with a strain of Staphylococcus aureus resistant to gentamicin and methicillin. Lancet. 1976 Dec 18;2(7999):1347–1348. doi: 10.1016/s0140-6736(76)91986-3. [DOI] [PubMed] [Google Scholar]
- Speller D. C., Raghunath D., Stephens M., Viant A. C., Reeves D. S., Wilkinson P. J., Broughall J. M., Holt H. A. Epidemic infection by a gentamicin-resistant Staphylococcus aureus in three hospitals. Lancet. 1976 Feb 28;1(7957):464–466. doi: 10.1016/s0140-6736(76)91485-9. [DOI] [PubMed] [Google Scholar]
- Wyatt T. D., Ferguson W. P., Wilson T. S., McCormick E. Gentamicin resistant Staphylococcus aureus associated with the use of topical gentamicin. J Antimicrob Chemother. 1977 May;3(3):213–217. doi: 10.1093/jac/3.3.213. [DOI] [PubMed] [Google Scholar]