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. 1983 Dec;91(3):535–541. doi: 10.1017/s0022172400060587

Exposure of water consumers to mesophilic actinomycetes.

T H Ojanen, M L Katila, R Mäntyjärvi, H Seppänen, A Muittari, P Kuusisto, P Virtanen
PMCID: PMC2129329  PMID: 6663066

Abstract

In autumn 1978 an epidemic of respiratory disease resembling allergic alveolitis occurred in a small Finnish community. The disease was caused by repeated exposures to tap water aerosol. The raw water of the community and the sand filters of the purification system were heavily contaminated with mesophilic actinomycetes. Fourteen different strains of actinomycetes were isolated. Exposed persons with and without symptoms as well as unexposed control persons were tested for antibodies against five of these actinomycetes and against Enterobacter agglomerans. Both the exposed and the control persons had antibodies to actinomycetes but the exposed persons had antibodies against more actinomycete strains than the control persons. Precipitating antibodies against E. agglomerans were also found in control persons as well as in patients. There was a significant difference between the patients and the exposed healthy persons in bacterial agglutination tests with flagellar antigen of one E. agglomerans strain. However, the role of mesophilic actinomycetes and E. agglomerans in the aetiology of the disease could not be firmly established.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atterholm I., Ganrot-Norlin K., Hallberg T., Ringertz O. Unexplained acute fever after a hot bath. Lancet. 1977 Oct 1;2(8040):684–686. doi: 10.1016/s0140-6736(77)90496-2. [DOI] [PubMed] [Google Scholar]
  2. Dutkiewicz J. Studies on endotoxin of Erwinia herbicola and their biological activity. Zentralbl Bakteriol Orig A. 1976 Dec;236(4):487–508. [PubMed] [Google Scholar]
  3. Edwards J. H., Griffiths A. J., Mullins J. Protozoa as sources of antigen in 'humidifier fever'. Nature. 1976 Dec 2;264(5585):438–439. doi: 10.1038/264438a0. [DOI] [PubMed] [Google Scholar]
  4. Edwards J. H. Microbial and immunological investigations and remedial action after an outbreak of humidifier fever. Br J Ind Med. 1980 Feb;37(1):55–62. doi: 10.1136/oem.37.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GREGORY P. H., LACEY M. E. Mycological examination of dust from mouldy hay associated with farmer's lung disease. J Gen Microbiol. 1963 Jan;30:75–88. doi: 10.1099/00221287-30-1-75. [DOI] [PubMed] [Google Scholar]
  6. Katila M. L., Mäntjärvi R. A. The diagnostic value of antibodies to the traditional antigens of farmer's lung in Finland. Clin Allergy. 1978 Nov;8(6):581–587. doi: 10.1111/j.1365-2222.1978.tb01512.x. [DOI] [PubMed] [Google Scholar]
  7. Metzger W. J., Patterson R., Fink J., Semerdjian R., Roberts M. Sauna-takers disease. Hypersensitivity pneumonitis due to contaminated water in a home sauna. JAMA. 1976 Nov 8;236(19):2209–2211. doi: 10.1001/jama.236.19.2209. [DOI] [PubMed] [Google Scholar]
  8. Muittari A., Kuusisto P., Virtanen P., Sovijärvi A., Grönroos P., Harmoinen A., Antila P., Kellomäki L. An epidemic of extrinsic allergic alveolitis caused by tap water. Clin Allergy. 1980 Jan;10(1):77–90. doi: 10.1111/j.1365-2222.1980.tb02083.x. [DOI] [PubMed] [Google Scholar]
  9. Muittari A., Rylander R., Salkinoja-Salonen M. Endotoxin and bath-water fever. Lancet. 1980 Jul 12;2(8185):89–89. doi: 10.1016/s0140-6736(80)92965-7. [DOI] [PubMed] [Google Scholar]
  10. Niemi R. M., Knuth S., Lundström K. Actinomycetes and fungi in surface waters and in potable water. Appl Environ Microbiol. 1982 Feb;43(2):378–388. doi: 10.1128/aem.43.2.378-388.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. PEPYS J., JENKINS P. A. PRECIPITIN (F.L.H.) TEST IN FARMER'S LUNG. Thorax. 1965 Jan;20:21–35. doi: 10.1136/thx.20.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Patterson R., Fink J. N., Miles W. B., Basich J. E., Schleuter D. B., Tinkelman D. G., Roberts M. Hypersensitivity lung disease presumptively due to Cephalosporium in homes contaminated by sewage flooding or by humidifier water. J Allergy Clin Immunol. 1981 Aug;68(2):128–132. doi: 10.1016/0091-6749(81)90171-8. [DOI] [PubMed] [Google Scholar]
  13. Patterson R., Fink J. N., Roberts M., Kelly J. F., Sommers H. M. Antibody activity in sera of patients with humidifier disease: studies of the water supply as a source of antigens. J Allergy Clin Immunol. 1978 Aug;62(2):103–108. doi: 10.1016/0091-6749(78)90086-6. [DOI] [PubMed] [Google Scholar]
  14. Pickering C. A., Moore W. K., Lacey J., Holford-Strevens V., Pepys J. Investigation of a respiratory disease associated with an air-conditioning system. Clin Allergy. 1976 Mar;6(2):109–118. doi: 10.1111/j.1365-2222.1976.tb01888.x. [DOI] [PubMed] [Google Scholar]
  15. Rylander R., Haglind P., Lundholm M., Mattsby I., Stenqvist K. Humidifier fever and endotoxin exposure. Clin Allergy. 1978 Sep;8(5):511–516. doi: 10.1111/j.1365-2222.1978.tb01504.x. [DOI] [PubMed] [Google Scholar]
  16. Rylander R., Lundholm M. Bacterial contamination of cotton and cotton dust and effects on the lung. Br J Ind Med. 1978 Aug;35(3):204–207. doi: 10.1136/oem.35.3.204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Schatz M., Patterson R., Fink J. Immunopatholgenesis of hypersensitivity pneumonitis. J Allergy Clin Immunol. 1977 Jul;60(1):27–37. doi: 10.1016/0091-6749(77)90079-3. [DOI] [PubMed] [Google Scholar]
  18. TENDLER M. D., BURKHOLDER P. R. Studies on the thermophilic actinomycetes. I. Methods of cultivation. Appl Microbiol. 1961 Sep;9:394–399. doi: 10.1128/am.9.5.394-399.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Terho E. O., Lacey J. Microbiological and serological studies of farmers' lung in Finland. Clin Allergy. 1979 Jan;9(1):43–52. doi: 10.1111/j.1365-2222.1979.tb01521.x. [DOI] [PubMed] [Google Scholar]

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