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. 1985 Feb;94(1):45–54. doi: 10.1017/s0022172400061118

The virulence of clinical and environmental isolates of Campylobacter jejuni.

D G Newell, H McBride, F Saunders, Y Dehele, A D Pearson
PMCID: PMC2129391  PMID: 3973380

Abstract

The virulence of Campylobacter jejuni and C. coli isolated from various water sources was compared with that of clinical strains by in vitro assays of adhesion, invasion and cytotoxicity to HeLa cells. Variation in degree of attachment was observed, but this did not appear to be related to strain source, However, water strains were less invasive and less cytotoxic to HeLa cells than clinical strains as shown by immunofluorescence and electron microscopy. These differences were particularly evident between clinical and water isolates of the same serotype and biotype implicated in an outbreak of campylobacter enteritis in a school. The enhanced virulence of the clinical isolates, possibly induced by passage, was confirmed by colonization tests on infant mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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