Skip to main content
The Journal of Hygiene logoLink to The Journal of Hygiene
. 1984 Dec;93(3):397–404. doi: 10.1017/s0022172400064998

The diphtheria bacillus and its toxin: a model system.

A M Pappenheimer Jr
PMCID: PMC2129457  PMID: 6439779

Full text

PDF

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bacha P., Murphy J. R., Reichlin S. Organ-specific binding of a thyrotropin-releasing hormone-diphtheria toxin complex after intravenous administration to rats. Endocrinology. 1983 Sep;113(3):1072–1076. doi: 10.1210/endo-113-3-1072. [DOI] [PubMed] [Google Scholar]
  2. Boquet P., Duflot E. Tetanus toxin fragment forms channels in lipid vesicles at low pH. Proc Natl Acad Sci U S A. 1982 Dec;79(24):7614–7618. doi: 10.1073/pnas.79.24.7614. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Codina J., Hildebrandt J., Iyengar R., Birnbaumer L., Sekura R. D., Manclark C. R. Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium. Proc Natl Acad Sci U S A. 1983 Jul;80(14):4276–4280. doi: 10.1073/pnas.80.14.4276. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Collier R. J. Diphtheria toxin: mode of action and structure. Bacteriol Rev. 1975 Mar;39(1):54–85. doi: 10.1128/br.39.1.54-85.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Collier R. J., Westbrook E. M., McKay D. B., Eisenberg D. X-ray grade crystals of diphtheria toxin. J Biol Chem. 1982 May 10;257(9):5283–5285. [PubMed] [Google Scholar]
  6. Donovan J. J., Simon M. I., Draper R. K., Montal M. Diphtheria toxin forms transmembrane channels in planar lipid bilayers. Proc Natl Acad Sci U S A. 1981 Jan;78(1):172–176. doi: 10.1073/pnas.78.1.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Eidels L., Proia R. L., Hart D. A. Membrane receptors for bacterial toxins. Microbiol Rev. 1983 Dec;47(4):596–620. doi: 10.1128/mr.47.4.596-620.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. FREEMAN V. J. Studies on the virulence of bacteriophage-infected strains of Corynebacterium diphtheriae. J Bacteriol. 1951 Jun;61(6):675–688. doi: 10.1128/jb.61.6.675-688.1951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Finn C. W., Jr, Silver R. P., Habig W. H., Hardegree M. C., Zon G., Garon C. F. The structural gene for tetanus neurotoxin is on a plasmid. Science. 1984 May 25;224(4651):881–884. doi: 10.1126/science.6326263. [DOI] [PubMed] [Google Scholar]
  10. Greenfield L., Bjorn M. J., Horn G., Fong D., Buck G. A., Collier R. J., Kaplan D. A. Nucleotide sequence of the structural gene for diphtheria toxin carried by corynebacteriophage beta. Proc Natl Acad Sci U S A. 1983 Nov;80(22):6853–6857. doi: 10.1073/pnas.80.22.6853. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gyles C., So M., Falkow S. The enterotoxin plasmids of Escherichia coli. J Infect Dis. 1974 Jul;130(1):40–49. doi: 10.1093/infdis/130.1.40. [DOI] [PubMed] [Google Scholar]
  12. Jacewicz M., Keusch G. T. Pathogenesis of Shigella diarrhea. VIII. Evidence for a translocation step in the cytotoxic action of Shiga toxin. J Infect Dis. 1983 Nov;148(5):844–854. doi: 10.1093/infdis/148.5.844. [DOI] [PubMed] [Google Scholar]
  13. Kagan B. L., Finkelstein A., Colombini M. Diphtheria toxin fragment forms large pores in phospholipid bilayer membranes. Proc Natl Acad Sci U S A. 1981 Aug;78(8):4950–4954. doi: 10.1073/pnas.78.8.4950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Katada T., Ui M. ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity. J Biol Chem. 1982 Jun 25;257(12):7210–7216. [PubMed] [Google Scholar]
  15. Lory S., Collier R. J. Expression of enzymic activity by exotoxin A from Pseudomonas aeruginosa. Infect Immun. 1980 May;28(2):494–501. doi: 10.1128/iai.28.2.494-501.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. McKeever B., Sarma R. Preliminary crystallographic investigation of the protein toxin from corynebacterium diphtheriae. J Biol Chem. 1982 Jun 25;257(12):6923–6925. [PubMed] [Google Scholar]
  17. Mekalanos J. J. Duplication and amplification of toxin genes in Vibrio cholerae. Cell. 1983 Nov;35(1):253–263. doi: 10.1016/0092-8674(83)90228-3. [DOI] [PubMed] [Google Scholar]
  18. Pappenheimer A. M., Jr Diphtheria toxin. Annu Rev Biochem. 1977;46:69–94. doi: 10.1146/annurev.bi.46.070177.000441. [DOI] [PubMed] [Google Scholar]
  19. Pappenheimer A. M., Jr Diphtheria: studies on the biology of an infectious disease. Harvey Lect. 1980;76:45–73. [PubMed] [Google Scholar]
  20. Pappenheimer A. M., Jr, Murphy J. R. Studies on the molecular epidemiology of diphtheria. Lancet. 1983 Oct 22;2(8356):923–926. doi: 10.1016/s0140-6736(83)90449-x. [DOI] [PubMed] [Google Scholar]
  21. Ratti G., Rappuoli R., Giannini G. The complete nucleotide sequence of the gene coding for diphtheria toxin in the corynephage omega (tox+) genome. Nucleic Acids Res. 1983 Oct 11;11(19):6589–6595. doi: 10.1093/nar/11.19.6589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Righelato R. C., van Hemert P. A. Growth and toxin synthesis in batch and chemostat cultures of Corynebacterium diphtheriae. J Gen Microbiol. 1969 Nov;58(3):403–410. doi: 10.1099/00221287-58-3-403. [DOI] [PubMed] [Google Scholar]
  23. Uchida T., Gill D. M., Pappenheimer A. M., Jr Mutation in the structural gene for diphtheria toxin carried by temperate phage . Nat New Biol. 1971 Sep 1;233(35):8–11. doi: 10.1038/newbio233008a0. [DOI] [PubMed] [Google Scholar]
  24. Van Ness B. G., Howard J. B., Bodley J. W. ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products. J Biol Chem. 1980 Nov 25;255(22):10710–10716. [PubMed] [Google Scholar]
  25. Vasil M. L., Iglewski B. H. Comparative toxicities of diphtherial toxin and Pseudomonas aeruginosa exotoxin A: evidence for different cell receptors. J Gen Microbiol. 1978 Oct;108(2):333–337. doi: 10.1099/00221287-108-2-333. [DOI] [PubMed] [Google Scholar]
  26. Yamaizumi M., Mekada E., Uchida T., Okada Y. One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell. Cell. 1978 Sep;15(1):245–250. doi: 10.1016/0092-8674(78)90099-5. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Hygiene are provided here courtesy of Cambridge University Press

RESOURCES