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. 1985 Jun;94(3):279–288. doi: 10.1017/s0022172400061507

Carriage of Neisseria meningitidis and Neisseria lactamica in a school population during an epidemic period in Spain.

J A Saez-Nieto, J R Dominguez, J L Monton, P Cristobal, A Fenoll, J Vazquez, J Casal, B Taracena
PMCID: PMC2129489  PMID: 3924995

Abstract

A study was made of the incidence of Neisseria meningitidis and N. lactamica in a school population; 2470 children aged between 5 and 7 years were studied from four schools in Alcala de Henares (Madrid). Nasopharyngeal swabs were taken in June, November and March, between 1979 and 1983. In all the surveys except one, the proportion of carriers of N. lactamica was higher than that of N. meningitidis, reaching a ratio of about 2:1 in the complete study. The predominant serogroup of meningococcus found was B (41%), with nongroupable strains reaching 43%. A study of serotypes within group B showed a predominance of nontypable strains (48.5%), while those strains considered to be most virulent (types 2 and 1, 8, 15) reached 40%. Eighteen per cent of N. lactamica strains were observed to agglutinate with antimeningococcal sera whilst the remainder of the strains were rough. When these strains were studied with the antiserum-agar technique, using antimeningococcal sera, a high percentage of strains cross-reacted with the meningococci. The susceptibility of strains to sulphadiazine, penicillin, ampicillin, chloramphenicol, rifampicin and spiramycin was determined. Finally an analysis was made of the effect that an elevated colonization rate of N. lactamica might have on colonization by meningococci. The necessity of using fine epidemiological markers in tracing virulent strains in a population at risk is stressed. Selective prophylactic measures are also necessary.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AYCOCK W. L., MUELLER J. H. Meningococcus carrier rates and meningitis incidence. Bacteriol Rev. 1950 Jun;14(2):115–160. doi: 10.1128/br.14.2.115-160.1950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Blakebrough I. S., Greenwood B. M., Whittle H. C., Bradley A. K., Gilles H. M. The epidemiology of infections due to Neisseria meningitidis and Neisseria lactamica in a northern Nigerian community. J Infect Dis. 1982 Nov;146(5):626–637. doi: 10.1093/infdis/146.5.626. [DOI] [PubMed] [Google Scholar]
  3. Casal Lombos J., Martín Bourgón C. Estudio bacteriológico e inmunológico de meningococo en una población escolar. Rev Sanid Hig Publica (Madr) 1975 Feb;49(2):179–192. [PubMed] [Google Scholar]
  4. Corey G., Rodríguez H., Aguilar C., Greve E., Bustos R., Valenzuela M. E. Portadores de meningococos. Bol Oficina Sanit Panam. 1979 Sep;87(3):238–246. [PubMed] [Google Scholar]
  5. Craven D. E., Frasch C. E., Mocca L. F., Rose F. B., Gonzalez R. Rapid serogroup identification of Neisseria meningitidis by using antiserum agar: Prevalence of serotypes in a disease-free military population. J Clin Microbiol. 1979 Sep;10(3):302–307. doi: 10.1128/jcm.10.3.302-307.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Craven D. E., Frasch C. E., Robbins J. B., Feldman H. A. Serogroup identification of Neisseria meningitidis: comparison of an antiserum agar method with bacterial slide agglutination. J Clin Microbiol. 1978 May;7(5):410–414. doi: 10.1128/jcm.7.5.410-414.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. De Maeyer S., Seba J. M., Reginster G. Epidemiology of meningococcal meningitis in Belgium. J Infect. 1981 Mar;3(1 Suppl):63–70. doi: 10.1016/s0163-4453(81)80010-2. [DOI] [PubMed] [Google Scholar]
  8. De Wals P., Gilquin C., De Maeyer S., Bouckaert A., Noel A., Lechat M. F., Lafontaine A. Longitudinal study of asymptomatic meningococcal carriage in two Belgian populations of schoolchildren. J Infect. 1983 Mar;6(2):147–156. doi: 10.1016/s0163-4453(83)92756-1. [DOI] [PubMed] [Google Scholar]
  9. Frasch C. E., Mocca L. F. Strains of Neisseria meningitidis isolated from patients and their close contacts. Infect Immun. 1982 Jul;37(1):155–159. doi: 10.1128/iai.37.1.155-159.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gelosa L. Frequenza e caratterizzazione della "Neisseria lactamica" nella popolazione milanese. Ann Sclavo. 1981 May-Jun;23(3):275–281. [PubMed] [Google Scholar]
  11. Gold R., Goldschneider I., Lepow M. L., Draper T. F., Randolph M. Carriage of Neisseria meningitidis and Neisseria lactamica in infants and children. J Infect Dis. 1978 Feb;137(2):112–121. doi: 10.1093/infdis/137.2.112. [DOI] [PubMed] [Google Scholar]
  12. Hassan-King M., Greenwood B. M., Whittle H. C., Abbott J. D., Sutcliffe E. M. An epidemic of meningococcal infection at Zaria, Northern Nigeria. 3. Meningococcal carriage. Trans R Soc Trop Med Hyg. 1979;73(5):567–573. doi: 10.1016/0035-9203(79)90054-3. [DOI] [PubMed] [Google Scholar]
  13. Holten E. Serotypes of Neisseria meningitidis isolated from patients in Norway during the first six months of 1978. J Clin Microbiol. 1979 Feb;9(2):186–188. doi: 10.1128/jcm.9.2.186-188.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Riou J. Y., Guibourdenche M., Popoff M. Y. A new taxon in the genus Neisseria. Ann Microbiol (Paris) 1983 Sep-Oct;134B(2):257–267. doi: 10.1016/s0769-2609(83)80038-6. [DOI] [PubMed] [Google Scholar]
  15. Saez-Nieto J. A., Campos J., Latorre C., Juncosa T., Sierra M., Garcia-Tornell T., Garcia-Barreno B., Lopez-Galindez C., Casal J. Prevalence of Neisseria meningitidis in family members of patients with meningococcal infection. J Hyg (Lond) 1982 Aug;89(1):139–148. doi: 10.1017/s0022172400070637. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Sáez Nieto J. A., Barcia Barrero B., López Galindez C., Casal J. Meningitis meningocócica en España (1978-1980). II. Serotipos y patrones electroforéticos en gel de poliacrilamida. Rev Sanid Hig Publica (Madr) 1981 Nov-Dec;55(11-12):1295–1308. [PubMed] [Google Scholar]
  17. Sáez Nieto J. A., Llacer A., Catalá F., Fenoll A., Casal J. Meningitis meningocócica en España (1978-1980). I. Estudios epidemiológicos, serogrupos y sensibilidad a antimicrobianos. Rev Sanid Hig Publica (Madr) 1981 Jul-Aug;55(7-8):831–869. [PubMed] [Google Scholar]
  18. Sáez Nieto J. A., Vázquez J., Casal J. Meningitis meningocócica en España (1978-1981). III. Susceptibilidad de las cepas de meningococo aisladas de enfermos y portadores, frente a los principales agentes usados en el tratamiento y la quimioprofilaxis de la infección meningocócica. Rev Sanid Hig Publica (Madr) 1983 May-Jun;57(5-6):587–602. [PubMed] [Google Scholar]
  19. Sáez-Nieto J. A., Perucha M., Casamayor H., Marcen J. J., Llacer A., Garcia-Barreno B., Casal J. Outbreak of infection caused by Neisseria meningitidis group C type 2 in a nursery. J Infect. 1984 Jan;8(1):49–55. doi: 10.1016/s0163-4453(84)93327-9. [DOI] [PubMed] [Google Scholar]
  20. Wenzel R. P., Davies J. A., Mitzel J. R., Beam W. E., Jr Non-usefulness of meningococcal carriage-rates. Lancet. 1973 Jul;2(7822):205–205. doi: 10.1016/s0140-6736(73)93037-7. [DOI] [PubMed] [Google Scholar]

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