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. 1985 Oct;95(2):419–436. doi: 10.1017/s0022172400062859

The estimation of age-related rates of infection from case notifications and serological data.

B T Grenfell, R M Anderson
PMCID: PMC2129533  PMID: 4067297

Abstract

The paper describes a maximum-likelihood method for the estimation of age-related changes in the per capita rate of infection, from case notification records or serological data. The methods are applied to records of measles incidence in the UK and USA, for which the estimated rates of infection tend to rise to a maximum value at around 10 years of age and then to decline in the older age-classes. Longer-term and seasonal trends are analysed by reference to changes in the estimated average age at infection; a statistic derived from a knowledge of the age-specific rates of infection. Future data needs in the epidemiological study of directly transmitted viral and bacterial diseases are discussed with reference to the detection and interpretation of age-dependent rates of disease transmission.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson R. M., Grenfell B. T., May R. M. Oscillatory fluctuations in the incidence of infectious disease and the impact of vaccination: time series analysis. J Hyg (Lond) 1984 Dec;93(3):587–608. doi: 10.1017/s0022172400065177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anderson R. M., May R. M. Age-related changes in the rate of disease transmission: implications for the design of vaccination programmes. J Hyg (Lond) 1985 Jun;94(3):365–436. doi: 10.1017/s002217240006160x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Anderson R. M., May R. M. Directly transmitted infections diseases: control by vaccination. Science. 1982 Feb 26;215(4536):1053–1060. doi: 10.1126/science.7063839. [DOI] [PubMed] [Google Scholar]
  4. Anderson R. M., May R. M. Vaccination against rubella and measles: quantitative investigations of different policies. J Hyg (Lond) 1983 Apr;90(2):259–325. doi: 10.1017/s002217240002893x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BLACK F. L. Measles antibodies in the population of New Haven, Connecticut. J Immunol. 1959 Jul;83(1):74–82. [PubMed] [Google Scholar]
  6. Fine P. E., Clarkson J. A. Measles in England and Wales--I: An analysis of factors underlying seasonal patterns. Int J Epidemiol. 1982 Mar;11(1):5–14. doi: 10.1093/ije/11.1.5. [DOI] [PubMed] [Google Scholar]
  7. Fine P. E., Clarkson J. A. Measles in England and Wales--II: The impact of the measles vaccination programme on the distribution of immunity in the population. Int J Epidemiol. 1982 Mar;11(1):15–25. doi: 10.1093/ije/11.1.15. [DOI] [PubMed] [Google Scholar]
  8. Godfrey E. S. The Age Distribution of Communicable Disease According to Size of Community. Am J Public Health Nations Health. 1928 May;18(5):616–631. doi: 10.2105/ajph.18.5.616. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. London W. P., Yorke J. A. Recurrent outbreaks of measles, chickenpox and mumps. I. Seasonal variation in contact rates. Am J Epidemiol. 1973 Dec;98(6):453–468. doi: 10.1093/oxfordjournals.aje.a121575. [DOI] [PubMed] [Google Scholar]
  10. Public Health Weekly Reports for APRIL 5, 1929. Public Health Rep. 1929 Apr 5;44(14):763–864. [PMC free article] [PubMed] [Google Scholar]

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