Skip to main content
The Journal of Hygiene logoLink to The Journal of Hygiene
. 1985 Dec;95(3):695–702. doi: 10.1017/s0022172400060800

Investigation of the effectiveness of measles vaccination in children in Kenya

T M Bell, P M Tukei, G R Ademba, F M Mbugua, G W Gathara, J M Magana, P Kinyanjui, J Muli, D T G Hazlett, J E A Alwar, P C Kiptoon, V N M Kireti, A Waweru, R Mwavuo, M Mbogo, B Thiongo, D Kamande, T Munyeti, J Ortega
PMCID: PMC2129565  PMID: 3912434

Abstract

Laboratory studies were performed on 128 children clinically diagnosed as measles when seen at the Infectious Diseases Hospital, Kenyatta National Hospital (IDH), Nairobi (86 cases) and the Rural Health Training Centre, Maragua, Central Province (42 cases) between 9 July and 31 August 1984. A concurrent measles infection was confirmed in 95% of the children seen at IDH and in 85% of those seen at Maragua, with similar proportions of confirmations in children who had, and who had not, received measles vaccine. No differences in the number of sero-conversions nor in the absolute levels of acute or convalescent HI antibody titres could be detected between vaccinated and unvaccinated children. Analysis of the cases seen at Maragua indicates that about two thirds of the children who had received vaccine were protected. A pilot study of vaccinating children at 8 months and again at 12-13 months is suggested in an attempt to eradicate measles.

Full text

PDF
695

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Heymann D. L., Mayben G. K., Murphy K. R., Guyer B., Foster S. O. Measles control in Yaounde: justification of a one dose, nine month minimum age vaccination policy in tropical Africa. Lancet. 1983 Dec 24;2(8365-66):1470–1472. doi: 10.1016/s0140-6736(83)90813-9. [DOI] [PubMed] [Google Scholar]
  2. Mcquillin J., Bell T. M., Gardner P. S., Downham P. S. Application of immunofluorescence to a study of measles. Arch Dis Child. 1976 Jun;51(6):411–419. doi: 10.1136/adc.51.6.411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Mitchell C. D., Balfour H. H., Jr Measles control: so near and yet so far. Prog Med Virol. 1985;31:1–42. [PubMed] [Google Scholar]
  4. Munube G. M. Measles sero-immunity in rural non-vaccinated children of Busoga District, Uganda. East Afr Med J. 1979 Jul;56(7):335–338. [PubMed] [Google Scholar]
  5. Remme J., Mandara M. P., Leeuwenburg J. The force of measles infection in East Africa. Int J Epidemiol. 1984 Sep;13(3):332–339. doi: 10.1093/ije/13.3.332. [DOI] [PubMed] [Google Scholar]
  6. Wafula E. M., Tukei P. M., Bell T. M., Nzanze H., Pamba A., Ndinya-Achola J. O., Hazlett D. T., Ademba G. R. How should primary health workers diagnose and treat acute respiratory infections (A R I)? East Afr Med J. 1984 Oct;61(10):736–744. [PubMed] [Google Scholar]

Articles from The Journal of Hygiene are provided here courtesy of Cambridge University Press

RESOURCES