Skip to main content
The Journal of Hygiene logoLink to The Journal of Hygiene
. 1986 Apr;96(2):143–151. doi: 10.1017/s0022172400065918

The protection of infant mice from colonization with Campylobacter jejuni by vaccination of the dams.

J M Dolby, D G Newell
PMCID: PMC2129651  PMID: 3701036

Abstract

Intraperitoneal vaccination of female mice, before mating, with a whole cell, heat-killed (62 degrees C) vaccine of Campylobacter jejuni allowed the mother to confer immunity to her young, challenged orally 4-6 days after birth with the homologous strain. There was no protection against a strain of another serotype. Heating the vaccine to 100 degrees C destroyed its protective properties. A vaccine prepared from an aflagellate variant of the original strain was as protective as the original vaccine against challenge with the flagellated strain. Anti-flagellar serum antibody titres of the dams did not correlate with protection of their young.

Full text

PDF
143

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Attridge S. R., Rowley D. The role of the flagellum in the adherence of Vibrio cholerae. J Infect Dis. 1983 May;147(5):864–872. doi: 10.1093/infdis/147.5.864. [DOI] [PubMed] [Google Scholar]
  2. Blaser M. J., Reller L. B. Campylobacter enteritis. N Engl J Med. 1981 Dec 10;305(24):1444–1452. doi: 10.1056/NEJM198112103052404. [DOI] [PubMed] [Google Scholar]
  3. Bokkenheuser V. D., Richardson N. J., Bryner J. H., Roux D. J., Schutte A. B., Koornhof H. J., Freiman I., Hartman E. Detection of enteric campylobacteriosis in children. J Clin Microbiol. 1979 Feb;9(2):227–232. doi: 10.1128/jcm.9.2.227-232.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Field L. H., Underwood J. L., Pope L. M., Berry L. J. Intestinal colonization of neonatal animals by Campylobacter fetus subsp. jejuni. Infect Immun. 1981 Sep;33(3):884–892. doi: 10.1128/iai.33.3.884-892.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fitzgeorge R. B., Baskerville A., Lander K. P. Experimental infection of Rhesus monkeys with a human strain of Campylobacter jejuni. J Hyg (Lond) 1981 Jun;86(3):343–351. doi: 10.1017/s0022172400069096. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lambert M. E., Schofield P. F., Ironside A. G., Mandal B. K. Campylobacter colitis. Br Med J. 1979 Mar 31;1(6167):857–859. doi: 10.1136/bmj.1.6167.857. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lever A. M., Dolby J. M., Webster A. D., Price A. B. Chronic campylobacter colitis and uveitis in patient with hypogammaglobulinaemia. Br Med J (Clin Res Ed) 1984 Feb 18;288(6416):531–531. doi: 10.1136/bmj.288.6416.531. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lior H., Woodward D. L., Edgar J. A., Laroche L. J., Gill P. Serotyping of Campylobacter jejuni by slide agglutination based on heat-labile antigenic factors. J Clin Microbiol. 1982 May;15(5):761–768. doi: 10.1128/jcm.15.5.761-768.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Logan S. M., Trust T. J. Structural and antigenic heterogeneity of lipopolysaccharides of Campylobacter jejuni and Campylobacter coli. Infect Immun. 1984 Jul;45(1):210–216. doi: 10.1128/iai.45.1.210-216.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Naess V., Hofstad T. Chemical composition and biological activity of lipopolysaccharides prepared from type strains of Campylobacter jejuni and Campolybacter coli. Acta Pathol Microbiol Immunol Scand B. 1984 Aug;92(4):217–222. doi: 10.1111/j.1699-0463.1984.tb02824.x. [DOI] [PubMed] [Google Scholar]
  11. Newell D. G., McBride H., Dolby J. M. Investigations on the role of flagella in the colonization of infant mice with Campylobacter jejuni and attachment of Campylobacter jejuni to human epithelial cell lines. J Hyg (Lond) 1985 Oct;95(2):217–227. doi: 10.1017/s0022172400062653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Newell D. G., McBride H., Pearson A. D. The identification of outer membrane proteins and flagella of Campylobacter jejuni. J Gen Microbiol. 1984 May;130(5):1201–1208. doi: 10.1099/00221287-130-5-1201. [DOI] [PubMed] [Google Scholar]
  13. Newell D. G., McBride H., Saunders F., Dehele Y., Pearson A. D. The virulence of clinical and environmental isolates of Campylobacter jejuni. J Hyg (Lond) 1985 Feb;94(1):45–54. doi: 10.1017/s0022172400061118. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Newell D. G., Pearson A. The invasion of epithelial cell lines and the intestinal epithelium of infant mice by Campylobacter jejuni/coli. J Diarrhoeal Dis Res. 1984 Mar;2(1):19–26. [PubMed] [Google Scholar]
  15. Pead P. J. Electron microscopy of Campylobacter jejuni. J Med Microbiol. 1979 Aug;12(3):383–385. doi: 10.1099/00222615-12-3-383. [DOI] [PubMed] [Google Scholar]
  16. Penner J. L., Hennessy J. N. Passive hemagglutination technique for serotyping Campylobacter fetus subsp. jejuni on the basis of soluble heat-stable antigens. J Clin Microbiol. 1980 Dec;12(6):732–737. doi: 10.1128/jcm.12.6.732-737.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Price A. B., Dolby J. M., Dunscombe P. R., Stirling J. Detection of campylobacter by immunofluorescence in stools and rectal biopsies of patients with diarrhoea. J Clin Pathol. 1984 Sep;37(9):1007–1013. doi: 10.1136/jcp.37.9.1007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Price A. B., Jewkes J., Sanderson P. J. Acute diarrhoea: Campylobacter colitis and the role of rectal biopsy. J Clin Pathol. 1979 Oct;32(10):990–997. doi: 10.1136/jcp.32.10.990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rajan D. P., Mathan V. I. Prevalence of Campylobacter fetus subsp. jejuni in healthy populations in southern India. J Clin Microbiol. 1982 May;15(5):749–751. doi: 10.1128/jcm.15.5.749-751.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Ward T. T., Klein K., Borthistle B. K. Jejunal infection with Campylobacter. Arch Intern Med. 1984 May;144(5):1072–1074. [PubMed] [Google Scholar]
  21. Wenman W. M., Chai J., Louie T. J., Goudreau C., Lior H., Newell D. G., Pearson A. D., Taylor D. E. Antigenic analysis of Campylobacter flagellar protein and other proteins. J Clin Microbiol. 1985 Jan;21(1):108–112. doi: 10.1128/jcm.21.1.108-112.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Yancey R. J., Willis D. L., Berry L. J. Flagella-induced immunity against experimental cholera in adult rabbits. Infect Immun. 1979 Jul;25(1):220–228. doi: 10.1128/iai.25.1.220-228.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Hygiene are provided here courtesy of Cambridge University Press

RESOURCES