Abstract
Young adult mice were inoculated intravenously with strains JB or Peter C of Mycoplasma pulmonis. A few were inoculated intranasally with strain JB. This strain but not Peter C was isolated for 50 days or more from the urines of more than half of the mice. Those of strains TO, C3H and CBA, but not CFLP, were susceptible. Recovery of mycoplasmas was intermittent and sometimes the numbers isolated varied within individual mice and between mice of a particular strain, ranging from 5 X 10(1) to greater than or equal to 5 X 10(7) colour-changing units/ml. Fifty serial passes of M. pulmonis, strain JB, in mycoplasmal medium resulted in attenuation, the organisms after inoculation of TO mice not being recovered from the urine and excretion not being stimulated by treating the mice with progesterone. At autopsy, the organisms of early passage were usually but not invariably isolated from the kidneys of mice that had been urinary excretors. About half of the latter had no renal histopathological changes. The others had usually minimal renal perivascular lymphocytic infiltrates but occasionally more widespread inflammatory changes. The findings may have relevance to the spread of mycoplasmal infection within mouse colonies and suggest that an association between such infection and nephritis in other species, including man, should be sought more closely.
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- Denny F. W., Taylor-Robinson D., Allison A. C. The role of thymus-dependent immunity in Mycoplasma pulmonis infections of mice. J Med Microbiol. 1972 Aug;5(3):327–336. doi: 10.1099/00222615-5-3-327. [DOI] [PubMed] [Google Scholar]
- Furr P. M., Taylor-Robinson D. Enhancement of experimental Mycoplasma pulmonis infection of the mouse genital tract by progesterone treatment. J Hyg (Lond) 1984 Apr;92(2):139–144. doi: 10.1017/s0022172400064147. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hannan P. C. Observations on the arthritogenic properties of Sabin's type C murine mycoplasma (Mycoplasma histotropicum). J Gen Microbiol. 1971 Aug;67(3):363–365. doi: 10.1099/00221287-67-3-363. [DOI] [PubMed] [Google Scholar]
- Keystone E., Taylor-Robinson D., Pope C., Taylor G., Furr P. Effect of inherited deficiency of the fifth component of complement on arthritis induced in mice by Mycoplasma pulmonis. Arthritis Rheum. 1978 Sep-Oct;21(7):792–797. doi: 10.1002/art.1780210709. [DOI] [PubMed] [Google Scholar]
- Manchee R. J., Taylor-Robinson D. Haemadsorption and haemagglutination by mycoplasmas. J Gen Microbiol. 1968 Mar;50(3):465–478. doi: 10.1099/00221287-50-3-465. [DOI] [PubMed] [Google Scholar]
- Masiga W. N., Windsor R. S., Read W. C. A new mode of spread of contagious bovine pleuropneumonia? Vet Rec. 1972 Feb 26;90(9):247–248. doi: 10.1136/vr.90.9.247. [DOI] [PubMed] [Google Scholar]
- Scudamore J. M. Observations on the epidemiology of contagious bovine pleuropneumonia: Mycoplasma mycoides in urine. Res Vet Sci. 1976 May;20(3):330–333. [PubMed] [Google Scholar]
- Taylor-Robinson D., Furr P. M., Davies H. A., Manchee R. J., Mouches C., Bove J. M. Mycoplasmal adherence with particular reference to the pathogenicity of Mycoplasma pulmonis. Isr J Med Sci. 1981 Jul;17(7):599–603. [PubMed] [Google Scholar]
- Taylor-Robinson D., Furr P. M. The interplay of host and organism factors in infection of the mouse genital tract by Mycoplasma pulmonis. J Hyg (Lond) 1985 Aug;95(1):7–14. doi: 10.1017/s0022172400062227. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taylor G., Taylor-Robinson D., Slavin G. Effect of immunosuppression on arthritis in mice induced by Mycoplasma pulmonis. Ann Rheum Dis. 1974 Jul;33(4):376–384. doi: 10.1136/ard.33.4.376. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taylor G., Taylor-Robinson D. The part played by cell-mediated immunity in mycoplasma respiratory infections. Dev Biol Stand. 1975;28:195–210. [PubMed] [Google Scholar]
- Thomsen A. C. Mycoplasmas in human pyelonephritis: demonstration of antibodies in serum and urine. J Clin Microbiol. 1978 Aug;8(2):197–202. doi: 10.1128/jcm.8.2.197-202.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thomsen A. C. Occurrence of mycoplasmas in urinary tracts of patients with acute pyelonephritis. J Clin Microbiol. 1978 Jul;8(1):84–88. doi: 10.1128/jcm.8.1.84-88.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thomsen A. C. The occurrence of mycoplasmas in the urinary tract of patients with chronic pyelonephritis. Acta Pathol Microbiol Scand B. 1975 Feb;83(1):10–16. doi: 10.1111/j.1699-0463.1975.tb00063.x. [DOI] [PubMed] [Google Scholar]