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. 1986 Jun;96(3):523–528. doi: 10.1017/s0022172400066328

Age-dependent prevalence of BK virus IgG and IgM antibodies measured by enzyme-linked immunosorbent assays (ELISA).

T Flaegstad, T Traavik, B E Kristiansen
PMCID: PMC2129697  PMID: 3016078

Abstract

Enzyme immunoassays (ELISA) have been developed for the detection of BK virus IgG- and IgM-antibodies. Specific IgG is detected by an antigen-coated solid phase test; IgM by an antibody capture method. These methods have been used to study the age-distribution of BK virus antibodies in Tromsø county in Northern Norway. The serum panels tested were: 60 sera from paediatric patients aged 0-1 year; 220 sera from healthy persons aged 1-82 years; 74 sera from healthy blood donors; 107 sera from healthy pregnant women. The age-distribution of BKV-IgG antibodies showed that primary infections took place predominantly between the ages of 1 and 6 years, and that there were no sex differences, either in the age-specific prevalence or in the level of BKV-IgG. We found no significant differences in the prevalence of BKV-IgM antibodies in healthy children and adults and pregnant women. BKV-IgM was detected in 26 of the 461 sera tested (5.6%).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown D. W., Gardner S. D., Gibson P. E., Field A. M. BK virus specific IgM responses in cord sera, young children and healthy adults detected by RIA. Arch Virol. 1984;82(3-4):149–160. doi: 10.1007/BF01311159. [DOI] [PubMed] [Google Scholar]
  2. Brown P., Tsai T., Gajdusek D. C. Seroepidemiology of human papovaviruses. Discovery of virgin populations and some unusual patterns of antibody prevalence among remote peoples of the world. Am J Epidemiol. 1975 Oct;102(4):331–340. doi: 10.1093/oxfordjournals.aje.a112169. [DOI] [PubMed] [Google Scholar]
  3. Dei R., Marmo F., Corte D., Sampietro M. G., Franceschini E., Urbano P. Age-related changes in the prevalence of precipitating antibodies to BK virus in infants and children. J Med Microbiol. 1982 Aug;15(3):285–291. doi: 10.1099/00222615-15-3-285. [DOI] [PubMed] [Google Scholar]
  4. Flaegstad T., Traavik T. Detection of BK virus IgM antibodies by two enzyme-linked immunosorbent assays (ELISA) and a hemagglutination inhibition method. J Med Virol. 1985 Oct;17(2):195–204. doi: 10.1002/jmv.1890170212. [DOI] [PubMed] [Google Scholar]
  5. Flaegstad T., Traavik T. Detection of BK virus antibodies measured by enzyme-linked immunosorbent assay (ELISA) and two haemagglutination inhibition methods: a comparative study. J Med Virol. 1985 Aug;16(4):351–356. doi: 10.1002/jmv.1890160408. [DOI] [PubMed] [Google Scholar]
  6. Flower A. J., Banatvala J. E., Chrystie I. L. BK antibody and virus-specific IgM responses in renal transplant recipients, patients with malignant disease, and healthy people. Br Med J. 1977 Jul 23;2(6081):220–223. doi: 10.1136/bmj.2.6081.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gardner S. D., Field A. M., Coleman D. V., Hulme B. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet. 1971 Jun 19;1(7712):1253–1257. doi: 10.1016/s0140-6736(71)91776-4. [DOI] [PubMed] [Google Scholar]
  8. Gardner S. D. Prevalence in England of antibody to human polyomavirus (B.k.). Br Med J. 1973 Jan 13;1(5845):77–78. doi: 10.1136/bmj.1.5845.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gibson P. E., Field A. M., Gardner S. D., Coleman D. V. Occurrence of IgM antibodies against BK and JC polyomaviruses during pregnancy. J Clin Pathol. 1981 Jun;34(6):674–679. doi: 10.1136/jcp.34.6.674. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Goudsmit J., Wertheim-van Dillen P., van Strien A., van der Noordaa J. The role of BK virus in acute respiratory tract disease and the presence of BKV DNA in tonsils. J Med Virol. 1982;10(2):91–99. doi: 10.1002/jmv.1890100203. [DOI] [PubMed] [Google Scholar]
  11. Jung M., Krech U., Price P. C., Pyndiah M. N. Evidence of chronic persistent infections with polyomaviruses (BK type) in renal transplant recipients. Arch Virol. 1975;47(1):39–46. doi: 10.1007/BF01315591. [DOI] [PubMed] [Google Scholar]
  12. Mäntvjärvi R. A. New oncogenic human papovaviruses. Med Biol. 1979 Feb;57(1):29–35. [PubMed] [Google Scholar]
  13. Rziha H. J., Belohradsky B. H., Schneider U., Schwenk H. U., Bornkamm G. W., zur Hausen H. BK virus: II. Serologic studies in children with congenital disease and patients with malignant tumors and immunodeficiencies. Med Microbiol Immunol. 1978 Jul 4;165(2):83–92. doi: 10.1007/BF02122743. [DOI] [PubMed] [Google Scholar]
  14. Rziha H. J., Bornkamm G. W., zur Hausen H. BK virus: I. Seroepidemiologic studies and serologic response to viral infection. Med Microbiol Immunol. 1978 Jul 4;165(2):73–81. doi: 10.1007/BF02122742. [DOI] [PubMed] [Google Scholar]
  15. Shah K. V., Daniel R. W., Warszawski R. M. High prevalence of antibodies to BK virus, an SV40-related papovavirus, in residents of Maryland. J Infect Dis. 1973 Dec;128(6):784–787. doi: 10.1093/infdis/128.6.784. [DOI] [PubMed] [Google Scholar]
  16. Shah K., Daniel R., Madden D., Stagno S. Serological investigation of BK papovavirus infection in pregnant women and their offspring. Infect Immun. 1980 Oct;30(1):29–35. doi: 10.1128/iai.30.1.29-35.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]

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