Skip to main content
NCBI home page
The Journal of Hygiene logoLink to The Journal of Hygiene
. 1986 Jun;96(3):419–423. doi: 10.1017/s0022172400066183

In vitro and in vivo study of fosfomycin in methicillin-resistant Staphylococcus aureus septicaemia.

W Y Lau, C H Teoh-Chan, S T Fan, K F Lau
PMCID: PMC2129703  PMID: 3637200

Abstract

Five hundred strains of methicillin-resistant Staphylococcus aureus were tested against various anti-staphylococcal agents. Vancomycin, fusidic acid and fosfomycin were found to be the most effective. Only 1 strain out of 500 was resistant to fosfomycin. Three patients with methicillin-resistant Staphylococcus aureus septicaemia were successfully treated by fosfomycin. We conclude that fosfomycin could be the drug of choice for methicillin-resistant Staphylococcus aureus infection.

Full text

PDF
419

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allona A., Díaz Cabrera J. A., Manchado P. Fosfomycin in chronic urinary infections. Chemotherapy. 1977;23 (Suppl 1):267–274. doi: 10.1159/000222059. [DOI] [PubMed] [Google Scholar]
  2. Andrews J. M., Baquero F., Beltran J. M., Canton E., Crokaert F., Gobernado M., Gomez-Ius R., Loza E., Navarro M., Olay T. International collaborative study on standardization of bacterial sensitivity to fosfomycin. J Antimicrob Chemother. 1983 Oct;12(4):357–361. doi: 10.1093/jac/12.4.357. [DOI] [PubMed] [Google Scholar]
  3. Dai Z. Y., Zhang Y. Y., Zhang M. F., Zhang Z. L., Zhang J. D., Liu Y. K. Reevaluation of fosfomycin: clinical and laboratory studies. Chin Med J (Engl) 1981 Oct;94(10):645–652. [PubMed] [Google Scholar]
  4. Guenthner S. H., Wenzel R. P. In vitro activities of teichomycin, fusidic acid, flucloxacillin, fosfomycin, and vancomycin against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 1984 Aug;26(2):268–269. doi: 10.1128/aac.26.2.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hutzler R., Fernandes V., Muñoz D., Rozentraub A. Activity of fosfomycin in the treatment of bacterial infections. Chemotherapy. 1977;23 (Suppl 1):358–364. doi: 10.1159/000222076. [DOI] [PubMed] [Google Scholar]
  6. Kestle D. G., Kirby W. M. Clinical pharmacology and in vitro activity of phosphonomycin. Antimicrob Agents Chemother (Bethesda) 1969;9:332–337. [PubMed] [Google Scholar]
  7. Levine D. P., Cushing R. D., Jui J., Brown W. J. Community-acquired methicillin-resistant Staphylococcus aureus endocarditis in the Detroit Medical Center. Ann Intern Med. 1982 Sep;97(3):330–338. doi: 10.7326/0003-4819-97-3-330. [DOI] [PubMed] [Google Scholar]
  8. Myers J. P., Linnemann C. C., Jr Bacteremia due to methicillin-resistant Staphylococcus aureus. J Infect Dis. 1982 Apr;145(4):532–536. doi: 10.1093/infdis/145.4.532. [DOI] [PubMed] [Google Scholar]
  9. Neuman M. Recent developments in the field of phosphonic acid antibiotics. J Antimicrob Chemother. 1984 Oct;14(4):309–311. doi: 10.1093/jac/14.4.309. [DOI] [PubMed] [Google Scholar]
  10. Peacock J. E., Jr, Moorman D. R., Wenzel R. P., Mandell G. L. Methicillin-resistant Staphylococcus aureus: microbiologic characteristics, antimicrobial susceptibilities, and assessment of virulence of an epidemic strain. J Infect Dis. 1981 Dec;144(6):575–582. doi: 10.1093/infdis/144.6.575. [DOI] [PubMed] [Google Scholar]
  11. Thompson R. L., Fisher K. A., Wenzel R. P. In vitro activity of N-formimidoyl thienamycin and other beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 1982 Feb;21(2):341–343. doi: 10.1128/aac.21.2.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Thompson R. L., Wenzel R. P. International recognition of methicillin-resistant strains of Staphylococcus aureus. Ann Intern Med. 1982 Dec;97(6):925–926. doi: 10.7326/0003-4819-97-6-925. [DOI] [PubMed] [Google Scholar]
  13. Watanakunakorn C. A general survey of antibiotic treatment of staphylococcal septicaemia and endocarditis. Scand J Infect Dis Suppl. 1983;41:151–157. [PubMed] [Google Scholar]
  14. Watanakunakorn C., Guerriero J. C. Interaction between vancomycin and rifampin against Staphylococcus aureus. Antimicrob Agents Chemother. 1981 Jun;19(6):1089–1091. doi: 10.1128/aac.19.6.1089. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Watanakunakorn C. Treatment of infections due to methicillin-resistant Staphylococcus aureus. Ann Intern Med. 1982 Sep;97(3):376–378. doi: 10.7326/0003-4819-97-3-376. [DOI] [PubMed] [Google Scholar]
  16. Wenzel R. P. The emergence of methicillin-resistant Staphylococcus aureus. Ann Intern Med. 1982 Sep;97(3):440–442. doi: 10.7326/0003-4819-97-3-440. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Hygiene are provided here courtesy of Cambridge University Press

RESOURCES