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. 1978 Aug;81(1):25–30. doi: 10.1017/s0022172400053730

Serum antibody to poliovirus in patients in a mental deficiency hospital, with particular reference to Down's syndrome.

E McKay, G Hems, A Massie, M A Moffat, K M Phillips
PMCID: PMC2129762  PMID: 211162

Abstract

Neutralization tests for poliovirus antibodies were carried out on 74 patients in an adult mental deficiency hospital: 37 patients with Down's syndrome and 37 non-Down's mental defectives. The distribution of antibody titres to poliovirus types 1, 2 and 3 did not differ significantly between the two groups. Most patients had antibody to at least one poliovirus type but less than a third had antibodies at a titre of 1/8 or greater to all three types. The low level of poliovirus immunity in this population may be of epidemiological importance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adinolfi M., Gardner B., Martin W. Observations on the levels of gamma G, gamma A, gamma M globulins, anti-A and anti-B agglutinins, and antibodies to Escherichia coli in Down's anomaly. J Clin Pathol. 1967 Nov;20(6):860–864. doi: 10.1136/jcp.20.6.860. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Kyriazopoulou V. G., Bell E. J. A micrometabolic inhibition test for the estimation of poliovirus neutralizing antibodies. Bull World Health Organ. 1972;47(2):171–175. [PMC free article] [PubMed] [Google Scholar]
  3. Levin S., Nir E., Mogilner B. M. T system immune-deficiency in Down's syndrome. Pediatrics. 1975 Jul;56(1):123–126. [PubMed] [Google Scholar]
  4. Lopez V., Ochs H. D., Thuline H. C., Davis S. D., Wedgwood R. J. Defective antibody response to bacteriophage phichi 174 in Down syndrome. J Pediatr. 1975 Feb;86(2):207–211. doi: 10.1016/s0022-3476(75)80469-0. [DOI] [PubMed] [Google Scholar]
  5. Mortimer P. P., Cunningham P. Sero-immunity to poliovirus in children and young women: England 1972-4. J Hyg (Lond) 1975 Apr;74(2):283–287. doi: 10.1017/s0022172400024359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Reid D., Bell E. J., Grist N. R., Wilson T. S. Poliomyelitis: A gap in immunity? Lancet. 1973 Oct 20;2(7834):899–900. doi: 10.1016/s0140-6736(73)92022-9. [DOI] [PubMed] [Google Scholar]
  7. Rigas D. A., Elsasser P., Hecht F. Impaired in vitro response of circulating lymphocytes to phytohemagglutinin in Down's syndrome: dose- and time-response curves and relation to cellular immunity. Int Arch Allergy Appl Immunol. 1970;39(5-6):587–608. doi: 10.1159/000230384. [DOI] [PubMed] [Google Scholar]
  8. Sorrell T. C., Forbes I. J., Burness F. R., Rischbieth R. H. Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin). Lancet. 1971 Dec 4;2(7736):1233–1235. doi: 10.1016/s0140-6736(71)90547-2. [DOI] [PubMed] [Google Scholar]
  9. Thom H., McKay E. Gm antigenic titres in adults with Down's syndrome (mongolism), non-mongoloid mental defectives and healthy blood donors. Clin Exp Immunol. 1972 Dec;12(4):515–523. [PMC free article] [PubMed] [Google Scholar]

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