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. 1978 Oct;81(2):267–277. doi: 10.1017/s0022172400025109

The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice.

H J Field, P Wildy
PMCID: PMC2129783  PMID: 212476

Abstract

The pathogenicity for mice of two mutants of herpes simplex virus (type 1 and type 2), which fail to induce thymidine kinase, were compared with their respective parent strains. The mutants were much less virulent than the parents following either intracerebral or peripheral inoculation. The replication of the virus at the site of inoculation and its progression into the nervous system were studied. Following a very large inoculum in the ear, the type 1 mutant was found to establish a latent infection in the cervical dorsal root ganglia. Mice inoculated intracerebrally with small doses of the mutant viruses were solidly immune to challenge with lethal doses of the parent strain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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