Abstract
A technique for estimating antibodies to the neuraminidase antigens of influenza A is described. The antibody response to the haemagglutinin and neuraminidase antigens of influenza A (H3N2) was studied in a boys' public school over the four-year period 1970--4. During this time there were two outbreaks of influenza A and the effect of antibody on the result of natural challenge was investigated. No boy who had homotypic neuraminidase antibody had clinical influenza.
Full text
PDF











Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aymard-Henry M., Coleman M. T., Dowdle W. R., Laver W. G., Schild G. C., Webster R. G. Influenzavirus neuraminidase and neuraminidase-inhibition test procedures. Bull World Health Organ. 1973;48(2):199–202. [PMC free article] [PubMed] [Google Scholar]
- Couch R. B., Kasel J. A., Gerin J. L., Schulman J. L., Kilbourne E. D. Induction of partial immunity to influenza by a neuraminidase-specific vaccine. J Infect Dis. 1974 Apr;129(4):411–420. doi: 10.1093/infdis/129.4.411. [DOI] [PubMed] [Google Scholar]
- Dowdle W. R., Sarateanu D., Reimer C. B. Antiantibody enhancement of hemagglutination inhibition by influenza anti-neuraminidase. J Immunol. 1972 Dec;109(6):1321–1326. [PubMed] [Google Scholar]
- Hoskins T. W., Davies J. R., Smith A. J., Allchin A., Miller C. L., Pollock T. M. Influenza at Christ's Hospital: March, 1974. Lancet. 1976 Jan 17;1(7951):105–108. doi: 10.1016/s0140-6736(76)93151-2. [DOI] [PubMed] [Google Scholar]
- Murphy B. R., Kasel J. A., Chanock R. M. Association of serum anti-neuraminidase antibody with resistance to influenza in man. N Engl J Med. 1972 Jun 22;286(25):1329–1332. doi: 10.1056/NEJM197206222862502. [DOI] [PubMed] [Google Scholar]
- Schild G. C., Henry-Aymard M., Pereira H. G. A quantitative, single-radial-diffusion test for immunological studies with influenza virus. J Gen Virol. 1972 Aug;16(2):231–236. doi: 10.1099/0022-1317-16-2-231. [DOI] [PubMed] [Google Scholar]
- Slepushkin A. N., Schild G. C., Beare A. S., Chinn S., Tyrrell D. A. Neuraminidase and resistance to vaccination with live influenza A2 Hong Kong vaccines. J Hyg (Lond) 1971 Dec;69(4):571–578. doi: 10.1017/s0022172400021847. [DOI] [PMC free article] [PubMed] [Google Scholar]