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. 1978 Apr;80(2):243–248. doi: 10.1017/s0022172400053596

Immunity to challenge in volunteers vaccinated with an inactivated current or earlier strain of influenza A(H3N2).

H E Larson, D A Tyrrell, C H Bowker, C W Potter, G C Schild
PMCID: PMC2129992  PMID: 632564

Abstract

Volunteers were inoculated with vaccine made from the 30c mutant, A/Port Chalmers/73 or B/Hong Kong/8/73. Preliminary experiments showed that the 30 c strain was antigenically quite close to A/HK/8/68. Volunteers given 30c developed haemagglutination inhibiting antibodies against the 'current' 1973 serotypes (as well as to the vaccine virus) but the titres were less than those after the A/PC/73 vaccine. Volunteers were then challenged with a live attenuated virus, WRL 105, with A/Finland/4/74 antigens, by intranasal inoculation. The rates of infection were 43% after B/Hong Kong/8/73, 20% after 30c and 5% after A/PC/73. This indicated that the 30c gave some protection but that the vaccine prepared from the current strain gave more.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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