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. 1979 Apr;82(2):231–236. doi: 10.1017/s002217240002564x

Protection from natural infection after live influenza virus immunization in an open population.

G Rocchi, L Carlizza, M Andreoni, G Ragona, C Piga, A Pelosio, A Volpi, A Muzzi
PMCID: PMC2130141  PMID: 429787

Abstract

Live attenuated influenza vaccine containing the recombinant of A/Victoria/3/75 with A/PR/8/34 virus was administered to healthy adults in a field trial aimed at evaluating protection provided by immunization. The study was designed to measure the effect of vaccination on absenteeism from respiratory disease during a natural influenza epidemic. A total of 2115 male employees of the public transport service of Rome volunteered to participate in the trial, 1050 and 1065 receiving vaccine and placebo respectively, in a randomized blind fashion. Vaccination procedure was completed by the end of December 1976. A small-sized outbreak of influenza, due to a viral strain antigenically homologous to the vaccine, occurred during the month of February 1977. Analysis of absenteeism data, classified according to medical certificate, indicated that morbidity from respiratory disease was reduced in vaccinees compared with controls during the epidemic month; the rate of increase of morbidity compared with that of the preceding month was then three times lower in vaccinees than in controls and the difference in absenteeism between the two groups greatly exceeded the ordinary fluctuation that was observed during non-epidemic periods.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Donikian M. A., McKee J., Greene L. C. Challenge versus natural infection as an index or protection after influenza immunization. Dev Biol Stand. 1977 Jun 1;39:149–154. [PubMed] [Google Scholar]
  2. Kunz C., Hofmann H. Field study with a live influenza vaccine (RIT 4050) in children. Dev Biol Stand. 1977 Jun 1;39:93–97. [PubMed] [Google Scholar]
  3. Lobmann M., Delem A., Jovanović D. Properties of A/Victoria/3/75 recombinants: development of an attenuated strain RIT 4050. Dev Biol Stand. 1977 Jun 1;39:43–46. [PubMed] [Google Scholar]
  4. Mackenzie J. S., Mackenzie I., Lloyd J., Dent V. Comparative trials of live attenuated and detergent split influenza virus vaccines. J Hyg (Lond) 1975 Dec;75(3):425–443. doi: 10.1017/s0022172400024499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. McDonald J. C., Zuckerman A. J., Beare A. S., Tyrrell D. A. Trials of Live Influenza Vaccine in the Royal Air Force. Br Med J. 1962 Apr 14;1(5284):1036–1042. doi: 10.1136/bmj.1.5284.1036. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Minor T. E., Dick E. C., Dick C. R., Inhorn S. L. Attenuated influenza A vaccine (Alice) in an adult population: vaccine-related illness, serum and nasal antibody production, and intrafamily transmission. J Clin Microbiol. 1975 Nov;2(5):403–409. doi: 10.1128/jcm.2.5.403-409.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Murphy B. R., Chalhub E. G., Nusinoff S. R., Chanock R. M. Temperature-sensitive mutants of influenza virus. II. Attenuation of ts recombinants for man. J Infect Dis. 1972 Aug;126(2):170–178. doi: 10.1093/infdis/126.2.170. [DOI] [PubMed] [Google Scholar]
  8. Nicholson K. G., Lawford C. V., Tyrrell D. A. Studies of respiratory function in volunteers given live influenza virus vaccine. Dev Biol Stand. 1977 Jun 1;39:129–134. [PubMed] [Google Scholar]
  9. Petrilli F. L., Crovari P., Cuneo-Crovari P., Badolati G., Canepa R. Oral influenza vaccination with live attenuated viruses. 1. Acceptability, immunogenicity and transmissibility. Boll Ist Sieroter Milan. 1975 Oct 20;54(4):312–322. [PubMed] [Google Scholar]
  10. Prévost J. M., Peetermans J., Lamy F., Huygelen C. Immune response to vaccination with a live influenza virus (H3N2) vaccine ("Ann" strain). Infect Immun. 1973 Sep;8(3):420–424. doi: 10.1128/iai.8.3.420-424.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ragona G., Giunchi G., Rocchi G., Muzzi A., De Felici A. Excess mortality from influenza in a large urban population, Rome, Italy, 1956--76. J Hyg (Lond) 1978 Apr;80(2):249–257. doi: 10.1017/s0022172400053602. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rytel M. W., Jackson L. J., Ferstenfeld J. E., Rosenkranz M. A. New live attenuated influenza A/England/42/72 (H3N2) vaccine (Alice): reactogenicity,, immunogenicity, and protection efficacy. J Infect Dis. 1975 Dec;132(6):652–659. doi: 10.1093/infdis/132.6.652. [DOI] [PubMed] [Google Scholar]
  13. Rytel M. W., Jackson L. J., Niebojewski R. A., Haagensen J. L., Rosenkranz M. A. Field trial of live attenuated influenza A/B ("Alice"/R-75) vaccine. Am J Epidemiol. 1977 Jan;105(1):49–55. doi: 10.1093/oxfordjournals.aje.a112355. [DOI] [PubMed] [Google Scholar]
  14. SEVER J. L. Application of a microtechnique to viral serological investigations. J Immunol. 1962 Mar;88:320–329. [PubMed] [Google Scholar]
  15. Serfling Robert E. Methods for current statistical analysis of excess pneumonia-influenza deaths. Public Health Rep. 1963 Jun;78(6):494–506. [PMC free article] [PubMed] [Google Scholar]

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