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The Journal of Hygiene logoLink to The Journal of Hygiene
. 1972 Sep;70(3):531–543. doi: 10.1017/s0022172400063117

Antibody responses and resistance to challenge in volunteers vaccinated with live attenuated, detergent split and oil adjuvant A2/Hong Kong/68 (H3N2) influenza vaccines*

A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines

D S Freestone, Stephanie Hamilton-Smith, G C Schild, Rosemary Buckland, Susan Chinn, D A J Tyrrell
PMCID: PMC2130202  PMID: 4506997

Abstract

Forty-nine subjects were vaccinated with either live attenuated, detergent split, or oil adjuvant A2/Hong Kong influenza vaccines, or a saline influenza B vaccine as control. Respiratory symptoms occurred more frequently in subjects who received the live vaccine but in total there was little difference between the symptoms in the four groups. Antibody titres in nasal washings and serum were measured by haemagglutination inhibition, neuraminidase inhibition and virus neutralization tests. The oil adjuvant vaccine stimulated larger antibody responses than the other procedures. Six weeks after vaccination the volunteers were challenged with partially attenuated live A2/Hong Kong influenza virus administered intranasally. The live attenuated and oil adjuvant vaccines provided the best protection against challenge.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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