Abstract
Guanidine hydrochloride selectively inactivated both the biological activity and the immunogenicity of the haemagglutinin of influenza A/X-7 (HON2). The residual neuraminidase was fully active biologically and immunologically. The reverse was observed with influenza B/ROB; with this virus the haemagglutinin was resistant, and was immunogenic; while the neuraminidase was selectively inactivated, and was not immunogenic.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AMINOFF D. Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. Biochem J. 1961 Nov;81:384–392. doi: 10.1042/bj0810384. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Allan W. H., Madeley C. R., Kendal A. P. Studies with avian influenza A viruses: cross protection experiments in chickens. J Gen Virol. 1971 Aug;12(2):79–84. doi: 10.1099/0022-1317-12-2-79. [DOI] [PubMed] [Google Scholar]
- Chakraverty P. Antigenic relationships between the neuraminidases of influenza B virus. Bull World Health Organ. 1972;46(4):473–476. [PMC free article] [PubMed] [Google Scholar]
- Coleman M. T., Dowdle W. R., Pereira H. G., Schild G. C., Chang W. K. The Hong Kong-68 influenza A2 variant. Lancet. 1968 Dec 28;2(7583):1384–1386. doi: 10.1016/s0140-6736(68)92683-4. [DOI] [PubMed] [Google Scholar]
- David-West T. S. A new genetic marker for influenza virus subunits. Arch Gesamte Virusforsch. 1973;41(1):143–146. doi: 10.1007/BF01249941. [DOI] [PubMed] [Google Scholar]
- Kendal A. P., Biddle F., Belyavin G. Influenza virus neuraminidase and the viral surface. Biochim Biophys Acta. 1968 Oct 15;165(3):419–431. doi: 10.1016/0304-4165(68)90221-3. [DOI] [PubMed] [Google Scholar]
- Kilbourne E. D., Laver W. G., Schulman J. L., Webster R. G. Antiviral activity of antiserum specific for an influenza virus neuraminidase. J Virol. 1968 Apr;2(4):281–288. doi: 10.1128/jvi.2.4.281-288.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Laver W. G., Kilbourne E. D. Identification in a recombinant influenza virus of structural proteins derived from both parents. Virology. 1966 Nov;30(3):493–501. doi: 10.1016/0042-6822(66)90125-5. [DOI] [PubMed] [Google Scholar]
- Laver W. G., Valentine R. C. Morphology of the isolated hemagglutinin and neuraminidase subunits of influenza virus. Virology. 1969 May;38(1):105–119. doi: 10.1016/0042-6822(69)90132-9. [DOI] [PubMed] [Google Scholar]
- Murphy B. R., Kasel J. A., Chanock R. M. Association of serum anti-neuraminidase antibody with resistance to influenza in man. N Engl J Med. 1972 Jun 22;286(25):1329–1332. doi: 10.1056/NEJM197206222862502. [DOI] [PubMed] [Google Scholar]
- Schulman J. L., Khakpour M., Kilbourne E. D. Protective effects of specific immunity to viral neuraminidase on influenza virus infection of mice. J Virol. 1968 Aug;2(8):778–786. doi: 10.1128/jvi.2.8.778-786.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schulman J. L., Kilbourne E. D. Independent variation in nature of hemagglutinin and neuraminidase antigens of influenza virus: distinctiveness of hemagglutinin antigen of Hong Kong-68 virus. Proc Natl Acad Sci U S A. 1969 Jun;63(2):326–333. doi: 10.1073/pnas.63.2.326. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schulman J. L. The role of antineuraminidase antibody in immunity to influenza virus infection. Bull World Health Organ. 1969;41(3):647–650. [PMC free article] [PubMed] [Google Scholar]
- Slepushkin A. N., Schild G. C., Beare A. S., Chinn S., Tyrrell D. A. Neuraminidase and resistance to vaccination with live influenza A2 Hong Kong vaccines. J Hyg (Lond) 1971 Dec;69(4):571–578. doi: 10.1017/s0022172400021847. [DOI] [PMC free article] [PubMed] [Google Scholar]