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. 1975 Oct;75(2):237–247. doi: 10.1017/s0022172400047276

The differential transmissibility of Myxoma virus strains of differing virulence grades by the rabbit flea Spilopsyllus cuniculi (Dale).

A R Mead-Briggs, J A Vaughan
PMCID: PMC2130293  PMID: 1058245

Abstract

Laboratory studies showed that few rabbit fleas (Spilopsyllus cuniculi (Dale)) transmitted myxomatosis after removal from wild rabbits (Oryctolagus cuniculus (L) that had been infected for fever than 10-12 days, irrespective of the virulence of the myxoma virus strain involved. Rabbits infected with fully virulent (Grade I) strains died within 10-15 days and few fleas from these hosts became infective; averaging all the samples takem. 12% of the fleas were infective. Also, few fleas acquired infectivity on individual rabbits which covered from infection with attenuated strains; the mean was 8% infective. Rabbits which died between 17 and 44 days after infection had higher proportions of infective fleas at all sampling times; the mean was 42% infective. Male and female fleas transmitted virus with equal efficiency. For rabbits infected with any of the attenuated virus strains the mean percentage of infective fleas was inversely related to the survival time of the host. Rabbits infected with moderately attenuated strains (Grades IIIA and IIIB) had, on average, the highest proportion of infective fleas; hence such strains have a selective advantage and have become predominant under natural conditions in Britain. The changes that might occur if there is an increase in host resistance to myxomatosis are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDREWES C. H., THOMPSON H. V., MANSI W. Myxomatosis: present position and future prospects in Great Britain. Nature. 1959 Oct 17;184:1179–1180. doi: 10.1038/1841179a0. [DOI] [PubMed] [Google Scholar]
  2. CHAPPLE P. J., BOWEN E. T. A note on two attenuated strains of myxoma virus isolated in Great Britain. J Hyg (Lond) 1963 Jun;61:161–168. doi: 10.1017/s0022172400020866. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CHAPPLE P. J., MUIRHEAD-THOMSON R. C. EFFECT OF VARYING THE SITE OF INTRADERMAL INOCULATION OF MYXOMA VIRUS ON THE COURSE OF THE DISEASE. J Comp Pathol. 1964 Jul;74:366–372. doi: 10.1016/s0368-1742(64)80042-4. [DOI] [PubMed] [Google Scholar]
  4. FENNER F., CHAPPLE P. J. EVOLUTIONARY CHANGES IN MYXOMA VIRUS IN BRITAIN. AN EXAMINATION OF 222 NATURALLY OCCURRING STRAINS OBTAINED FROM 80 COUNTIES DURING THE PERIOD OCTOBER-NOVEMBER 1962. J Hyg (Lond) 1965 Jun;63:175–185. doi: 10.1017/s0022172400045083. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FENNER F. Changes in the mortality-rate due to myxomatosis in the Australian wild rabbit. Nature. 1953 Aug 8;172(4371):228–230. doi: 10.1038/172228a0. [DOI] [PubMed] [Google Scholar]
  6. FENNER F., DAY M. F., WOODROOFE G. M. Epidemiological consequences of the mechanical transmission of myxomatosis by mosquitoes. J Hyg (Lond) 1956 Jun;54(2):284–303. doi: 10.1017/s0022172400044521. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. FENNER F., DAY M. F., WOODROOFE G. M. The mechanism of the transmission of myxomatosis in the European rabbit (Oryctolagus cuniculus) by the mosquito Aedes aegypti. Aust J Exp Biol Med Sci. 1952 Apr;30(2):139–152. doi: 10.1038/icb.1952.13. [DOI] [PubMed] [Google Scholar]
  8. FENNER F., MARSHALL I. D. A comparison of the virulence for European rabbits (Oryctolagus cuniculus) of strains of myxoma virus recovered in the field in Australia, Europe and America. J Hyg (Lond) 1957 Jun;55(2):149–191. doi: 10.1017/s0022172400037098. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. FENNER F., MARSHALL I. D. Occurrence of attenuated strains of myxoma virus in Europe. Nature. 1955 Oct 22;176(4486):782–783. doi: 10.1038/176782a0. [DOI] [PubMed] [Google Scholar]
  10. HUDSON J. R., THOMPSON H. V., MANSI W. Myxoma virus in Britain. Nature. 1955 Oct 22;176(4486):783–783. doi: 10.1038/176783a0. [DOI] [PubMed] [Google Scholar]
  11. JACOTOT H., VALLEE A., VIRAT B. Apparition en France d'un mutant naturellement atténué du virus de Sanarelli. Ann Inst Pasteur (Paris) 1955 Sep;89(3):361–364. [PubMed] [Google Scholar]
  12. MARSHALL I. D., DOUGLAS G. W. Studies in the epidemiology of infectious myxomatosis of rabbits. VIII. Further observations on changes in the innate resistance of Australian wild rabbits exposed to myxomatosis. J Hyg (Lond) 1961 Mar;59:117–122. doi: 10.1017/s0022172400038766. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. MARSHALL I. D., FENNER F. Studies in the epidemiology of infectious myxomatosis of rabbits. V. Changes in the innate resistance of Australian wild rabbits exposed to myxomatosis. J Hyg (Lond) 1958 Jun;56(2):288–302. doi: 10.1017/s0022172400037773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. MARSHALL I. D., FENNER F. Studies in the epidemiology of infectious myxomatosis of rabbits. VII. The virulence of strains of myxoma virus recovered from Australian wild rabbits between 1951 and 1959. J Hyg (Lond) 1960 Dec;58:485–488. doi: 10.1017/s0022172400038614. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. MUIRHEAD-THOMSON R. C. Field studies of the role of Anopheles atroparvus in the transmission of myxomatosis in England. J Hyg (Lond) 1956 Dec;54(4):472–477. doi: 10.1017/s0022172400044752. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. MYKYTOWYCZ R. An attenuated strain of the myxomatosis virus recovered from the field. Nature. 1953 Sep 5;172(4375):448–449. doi: 10.1038/172448a0. [DOI] [PubMed] [Google Scholar]
  17. Service M. W. A reappraisal of the role of mosquitoes in the transmission of myxomatosis in Britain. J Hyg (Lond) 1971 Mar;69(1):105–111. doi: 10.1017/s0022172400021318. [DOI] [PMC free article] [PubMed] [Google Scholar]

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