Abstract
Both the haemagglutinin and the neuraminidase of influenza A2 virus have undergone progressive antigenic drift since this subtype first appeared in 1957.
In 1968 a strain showing a much greater antigenic difference was isolated in Hong Kong. This variant has been responsible for epidemics throughout the world in the past 2 years.
In the second year of its prevalence a small proportion of strains isolated showed a small but definite antigenic change, related principally to the haemagglutinin component.
This new variant formed about 4% of all strains investigated and was detected in Britain, Portugal, France and New Zealand.
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Selected References
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- Coleman M. T., Dowdle W. R., Pereira H. G., Schild G. C., Chang W. K. The Hong Kong-68 influenza A2 variant. Lancet. 1968 Dec 28;2(7583):1384–1386. doi: 10.1016/s0140-6736(68)92683-4. [DOI] [PubMed] [Google Scholar]
- MORRIS J. A., HATANO M., ROBINSON R. Q., AULISIO C. G., SMADEL J. E. ANTIGENIC RELATIONSHIP OF 1961-1963 A2 INFLUENZA VIRUSES TO PROTOTYPE A2 1957 STRAIN. Proc Soc Exp Biol Med. 1963 Nov;114:406–413. doi: 10.3181/00379727-114-28692. [DOI] [PubMed] [Google Scholar]
- PEREIRA H. G., PEREIRA M. S., LAW V. G. ANTIGENIC VARIANTS OF INFLUENZA A2 VIRUS. Bull World Health Organ. 1964;31:129–132. [PMC free article] [PubMed] [Google Scholar]
- Schild G. C. Antibody against influenza A2 virus neuraminidase in human sera. J Hyg (Lond) 1969 Jun;67(2):353–365. doi: 10.1017/s0022172400041759. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schild G. C., Newman R. W. Immunological relationships between the neuraminidases of human and animal influenza viruses. Bull World Health Organ. 1969;41(3):437–445. [PMC free article] [PubMed] [Google Scholar]
- Schulman J. L., Kilbourne E. D. The antigenic relationship of the neuraminidase of Hong Kong virus to that of other human strains of influenza A virus. Bull World Health Organ. 1969;41(3):425–428. [PMC free article] [PubMed] [Google Scholar]
- WEINBERGER H. L., BUESCHER E. L., MCCOWN J., GAULD J. R. ANTIGENIC VARIATION OF RECENTLY ISOLATED A2 INFLUENZA VIRUSES. Proc Soc Exp Biol Med. 1963 Nov;114:413–420. doi: 10.3181/00379727-114-28693. [DOI] [PubMed] [Google Scholar]
- Webster R. G., Laver W. G. Preparation and properties of antibody directed specifically against the neuraminidase of influenza virus. J Immunol. 1967 Jul;99(1):49–55. [PubMed] [Google Scholar]