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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1925 Oct 31;42(5):609–618. doi: 10.1084/jem.42.5.609

THE EFFECT OF ETHYL URETHANE ANESTHESIA ON THE ACID-BASE EQUILIBRIUM AND CELL CONTENTS OF THE BLOOD

James A Hawkins 1, James B Murphy 1
PMCID: PMC2131063  PMID: 19869077

Abstract

When anesthesia is produced in rabbits or rats by injections of ethyl urethane, the C02 content and pH of the whole blood of the animal are more or less rapidly increased to a point where there is a marked uncompensated alkalosis which reaches its maximum at 24 hours and persists for 48 hours. The increase in the C02 content and pH of the whole blood is accompanied by a decrease in the circulating lymphocytes and an increase in the polymorphonuclear leucocytes.

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Selected References

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  1. Van Slyke D. D. An Apparatus for Determination of the Gases in Blood and Other Solutions. Proc Natl Acad Sci U S A. 1921 Aug;7(8):229–231. doi: 10.1073/pnas.7.8.229. [DOI] [PMC free article] [PubMed] [Google Scholar]

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