Abstract
1. Four general types of spontaneous pneumonia, associated with strains of Bact. lepisepticum similar in biology and virulence, are described: (1) an acute, diffuse form, with subpleural and perivascular orientation of the exudate, (2) lobar, (3) pleuro-, and (4) abscess pneumonia. 2. The acute, diffuse, lobar, and pleuro pneumonias may be induced experimentally by intranasal instillation of a virulent strain of Bact. lepisepticum. 3. These same types occur when the organisms are inoculated intravenously, intratesticularly, and subcutaneously. 4. Intrabronchial insufflation of the organisms brings about infection in less than half of the animals. When effective, a sharply circumscribed, peribronchial lesion is found at the base of the lung, which spreads peripherally by direct extension, and generally by invasion of the blood stream. 5. It is concluded that differences in the types of pneumonia following infection with similar strains of Bact. lepisepticum depend upon the resistance of the animal, and that the usual portal of entry of this organism into the lungs, in cases of acute and lobar pneumonia, is by way of the blood stream.
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Selected References
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- Blake F. G., Cecil R. L. STUDIES ON EXPERIMENTAL PNEUMONIA : III. SPONTANEOUS PNEUMONIA IN MONKEYS. J Exp Med. 1920 Apr 30;31(5):499–518. doi: 10.1084/jem.31.5.499. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lamar R. V., Meltzer S. J. EXPERIMENTAL PNEUMONIA BY INTRABRONCHIAL INSUFFLATION. J Exp Med. 1912 Feb 1;15(2):133–148. doi: 10.1084/jem.15.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wadsworth A. B. STUDIES ON PNEUMOCOCCUS INFECTION IN ANIMALS : FIRST PAPER. J Exp Med. 1912 Jul 1;16(1):54–77. doi: 10.1084/jem.16.1.54. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Webster L. T., Baudisch O. BIOLOGY OF BACTERIUM LEPISEPTICUM : II. THE STRUCTURE OF SOME IRON COMPOUNDS WHICH INFLUENCE THE GROWTH OF CERTAIN BACTERIA OF THE HEMOPHILIC, ANAEROBIC, AND HEMORRHAGIC SEPTICEMIA GROUPS. J Exp Med. 1925 Sep 30;42(4):473–482. doi: 10.1084/jem.42.4.473. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Webster L. T. EPIDEMIOLOGICAL STUDIES ON RESPIRATORY INFECTIONS OF THE RABBIT : VIII. CARRIERS OF BACTERIUM LEPISEPTICUM. J Exp Med. 1926 Mar 31;43(4):573–588. doi: 10.1084/jem.43.4.573. [DOI] [PMC free article] [PubMed] [Google Scholar]