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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1927 Oct 31;46(5):699–707. doi: 10.1084/jem.46.5.699

VITAMIN A DEFICIENCY AND METAPLASIA

Harry Goldblatt 1, Maria Benischek 1
PMCID: PMC2131310  PMID: 19869366

Abstract

Of nineteen rats on a complete diet (Group III, Diet + C. L. O.), none showed foci of squamous keratinizing epithelium in abnormal situations. Of twenty-six rats on a diet deficient in vitamins A and D (Group I, Diet—A–D), twenty-three showed metaplastic changes of varying degree in one or more organs; the metaplasia was of columnar, cuboidal, and transitional epithelium to the squamous keratinizing type. Of eighteen rats on a diet deficient in vitamin A alone (Group II, Diet—A), seventeen showed epithelial metaplasia similar to that of Group I in one or more organs. In Groups I (Diet—A–D) and II (Diet—A) the changes occurred in one or more of the following organs: trachea, large bronchi, small bronchi or bronchioles in lung, posterior nares, accessory salivary glands of base of tongue, paraocular, submaxillary, sublingual, and parotid glands, renal pelvis, ureter, and bladder. The metaplastic changes were as extensive in the rats of Group II on a diet deficient in vitamin A alone as in those of Group I which received a diet deficient in vitamins A and D.

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Selected References

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  1. Wolbach S. B., Howe P. R. TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN. J Exp Med. 1925 Nov 30;42(6):753–777. doi: 10.1084/jem.42.6.753. [DOI] [PMC free article] [PubMed] [Google Scholar]

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