Abstract
1. Under proper conditions mass R cultures of Friedländer's bacillus may give rise to a number of variants which are dissimilar in colony appearance and morphology. Three such forms have been described. In two varieties, differences have been observed not only in colony formation and morphology, but also in cultural and antigenic characters. 2. None of the methods employed were adequate to cause reversion of any of the R variants to the S type. Growth of the R2 variant in its own antiserum, however, induced a change to the R1 form. 3. R forms of Friedländer's bacillus may be derived from S strains by aging or by growth in anti-S serum of the homologous type. 4. R strains may be isolated in culture directly from infection. In the cases where R forms were found, S cells were also present, and the pathological condition was of a chronic nature.
Full Text
The Full Text of this article is available as a PDF (850.9 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Avery O. T., Heidelberger M., Goebel W. F. THE SOLUBLE SPECIFIC SUBSTANCE OF FRIEDLANDER'S BACILLUS : PAPER II. CHEMICAL AND IMMUNOLOGICAL RELATIONSHIPS OF PNEUMOCOCCUS TYPE II AND OF A STRAIN OF FRIEDLANDER'S BACILLUS. J Exp Med. 1925 Oct 31;42(5):709–725. doi: 10.1084/jem.42.5.709. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Avery R. C., Leland S. J. A SIMPLE METHOD FOR THE ISOLATION OF PURE CULTURES FROM SINGLE BACTERIAL CELLS. J Exp Med. 1927 May 31;45(6):1003–1007. doi: 10.1084/jem.45.6.1003. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goebel W. F., Avery O. T. THE SOLUBLE SPECIFIC SUBSTANCE OF FRIEDLANDER'S BACILLUS : III. ON THE ISOLATION AND PROPERTIES OF THE SPECIFIC CARBOHYDRATES FROM TYPES A AND C FRIEDLANDER BACILLUS. J Exp Med. 1927 Sep 30;46(4):601–607. doi: 10.1084/jem.46.4.601. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heidelberger M., Avery O. T. THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : SECOND PAPER. J Exp Med. 1924 Aug 31;40(3):301–317. doi: 10.1084/jem.40.3.301. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Julianelle L. A. IMMUNOLOGICAL RELATIONSHIPS OF CELL CONSTITUENTS OF ENCAPSULATUS PNEUMONIAE (FRIEDLANDER'S BACILLUS). J Exp Med. 1926 Nov 30;44(6):735–751. doi: 10.1084/jem.44.6.735. [DOI] [PMC free article] [PubMed] [Google Scholar]