Abstract
1. Rabbits, vaccinated by repeated intravenous injections of suspensions of heat-killed R pneumococci, acquire a marked degree of active immunity to infection with the virulent S forms of Pneumococcus Types I and II. Previously (1) it was shown that the immunization of rabbits with R cells induces active resistance to Type III infection. This immunity is effective when the infecting organisms are injected either intravenously, intraperitoneally, or intradermally. 2. Whole citrated blood or serum of rabbits immunized with R pneumococci, under the experimental conditions described, is capable of passively protecting normal rabbits against Type I and Type III infection. Whole blood appears to be more effective than an equivalent amount of serum. 3. Passive protection of mice by the use of whole blood or serum of the immune rabbits has been entirely ineffectual. This is in striking contrast to the results obtained with type-specific immune serum. 4. This form of acquired resistance to pneumococcus infection, elicited by R organisms which are devoid of type specificity, and exemplified in animals whose sera possess no demonstrable type-specific antibodies, has many characteristics strongly suggesting that the underlying mechanism differs from that concerned in type-specific immunity.
Full Text
The Full Text of this article is available as a PDF (662.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cecil R. L., Blake F. G. STUDIES ON EXPERIMENTAL PNEUMONIA : V. ACTIVE IMMUNITY AGAINST EXPERIMENTAL PNEUMOCOCCUS PNEUMONIA IN MONKEYS FOLLOWING VACCINATION WITH LIVING CULTURES OF PNEUMOCOCCUS. J Exp Med. 1920 May 31;31(6):657–683. doi: 10.1084/jem.31.6.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cole R., Moore H. F. THE PRODUCTION OF ANTIPNEUMOCOCCIC SERUM. J Exp Med. 1917 Oct 1;26(4):537–561. doi: 10.1084/jem.26.4.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Goodner K. EXPERIMENTAL INTRADERMAL PNEUMOCOCCUS INFECTION IN RABBITS. J Exp Med. 1928 Jun 30;48(1):1–20. doi: 10.1084/jem.48.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tillett W. S. STUDIES ON IMMUNITY TO PNEUMOCOCCUS MUCOSUS (TYPE III) : I. ANTIBODY RESPONSE OF RABBITS IMMUNIZED WITH TYPE III PNEUMOCOCCUS. J Exp Med. 1927 Mar 31;45(4):713–726. doi: 10.1084/jem.45.4.713. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tillett W. S. STUDIES ON IMMUNITY TO PNEUMOCOCCUS MUCOSUS (TYPE III) : III. INCREASED RESISTANCE TO TYPE III INFECTION INDUCED IN RABBITS BY IMMUNIZATION WITH R AND S FORMS OF PNEUMOCOCCUS. J Exp Med. 1927 Jul 31;46(2):343–356. doi: 10.1084/jem.46.2.343. [DOI] [PMC free article] [PubMed] [Google Scholar]