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. 1975 Feb;74(1):7–16. doi: 10.1017/s0022172400046659

The production and preliminary investigation of Burulin, a new skin test reagent for Mycobacterium ulcerans infection.

J L Stanford, W D Revill, W J Gunthorpe, J M Grange
PMCID: PMC2131542  PMID: 1054061

Abstract

The preparation of a skin test antigen from Mycobacterium ulcerans by ultrasonic disintegration and filtration is described. The reagent, called Burulin, was tested in Africa in normal school children, and in patients with leprosy, tuberculosis or M. ulcerans disease. Those with tuberculosis or M. ulcerans disease were simultaneously tested with Tuberculin PPD. Burulin was found to be highly specific for patients in the reactive stage of M. ulcerans disease, and there was no cross-reaction in patients with other mycobacterioses. On the other hand, the majority of patients with M. ulcerans disease reacting to Burulin also produce positive reactions to Tuberculin PPD.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Stanford J. L. An immunodiffusion analysis of strains of Mycobacterium ulcerans isolated in Australia, Malaya, Mexico, Uganda and Zaire. J Med Microbiol. 1973 Aug;6(3):405–408. doi: 10.1099/00222615-6-3-405. [DOI] [PubMed] [Google Scholar]
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