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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1930 Feb 28;51(3):483–492. doi: 10.1084/jem.51.3.483

THE IMMUNOLOGICAL SIGNIFICANCE OF COLOSTRUM

II. THE INITIAL FEEDING OF SERUM FROM NORMAL COWS AND COWS IMMUNIZED TOWARDS B. COLI IN PLACE OF COLOSTRUM

Theobald Smith 1, Ralph B Little 1
PMCID: PMC2131831  PMID: 19869706

Abstract

Under certain safeguards, such as isolation, calves from a large dairy herd have been raised by feeding normal and immune cow serum in place of colostrum. The losses were about one out of ten in the later experiments. This outcome may probably be improved by the subcutaneous injection of serum during the first day. This loss may be no greater than that under ordinary conditions, since sporadic deaths among calves are not infrequent. However, no satisfactory statistics are available for comparison with results as given above.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Smith T., Bryant G. STUDIES ON PATHOGENIC B. COLI FROM BOVINE SOURCES : II. MUTATIONS AND THEIR IMMUNOLOGICAL SIGNIFICANCE. J Exp Med. 1927 Jun 30;46(1):133–140. doi: 10.1084/jem.46.1.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
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