Abstract
1. Following repeated intracutaneous injections of heat-killed pneumococci rabbits acquire an increased skin reactivity. 2. The increased skin reactivity reaches a maximum after 4 to 6 injections have been made, after which it becomes greatly diminished. 3. The relationship of increased skin reactivity to active resistance to infection by Pneumococcus, and to the presence of species-specific antibodies in the blood, is still obscure. 4. The increased skin reactivity is not transferable by serum from a highly reactive to a normal rabbit. 5. After regression of the reaction to the first injection of Pneumococcus into the skin, there frequently follows a recrudescence, or exacerbation, of the reaction. 6. The increased skin reactivity and secondary reactions are incited alike by all types and all forms of Pneumococcus.
Full Text
The Full Text of this article is available as a PDF (481.6 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Andrewes C. H., Derick C. L., Swift H. F. THE SKIN RESPONSE OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : I. DESCRIPTION OF A SECONDARY REACTION OCCURRING LOCALLY AFTER INTRADERMAL INOCULATION. J Exp Med. 1926 Jun 30;44(1):35–53. doi: 10.1084/jem.44.1.35. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Julianelle L. A. REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS : I. THE ANTIBODY RESPONSE. J Exp Med. 1930 Feb 28;51(3):441–448. doi: 10.1084/jem.51.3.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Julianelle L. A. REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS : II. RESISTANCE TO INFECTION. J Exp Med. 1930 Feb 28;51(3):449–462. doi: 10.1084/jem.51.3.449. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Swift H. F., Derick C. L. REACTIONS OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI : II. SKIN REACTIONS IN INTRAVENOUSLY IMMUNIZED ANIMALS. J Exp Med. 1929 Apr 30;49(5):883–897. doi: 10.1084/jem.49.5.883. [DOI] [PMC free article] [PubMed] [Google Scholar]